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NCT01404715 · ClinicalTrials.gov registry record · Phase 1
Drug-drug Interaction Study With Metformin and Imatinib
A Phase 1 study, sponsored by University of California, San Francisco.
- Completed
- Registry status
- Phase 1
- Development phase
- 11
- Enrollment target
NCT01404715 is a Phase 1 study that has completed, run by University of California, San Francisco. The registered enrollment target is 11 participants.
The verdict
NCT01404715, a Phase 1 study, has completed, sponsored by University of California, San Francisco.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 11 participants
- Enrollment target
Study Summary
This study will address the following question: Does imatinib influence the pharmacokinetics of metformin in healthy volunteers? Recent studies in the Giacomini laboratory have indicated that imatinib may block metformin elimination from the kidney by inhibiting organic cation transporter efflux of metformin. 1. The investigators hypothesize that the addition of imatinib to metformin therapy will reduce the renal clearance (CLR) of metformin leading to increased plasma concentrations and risk for toxicities 2. Knowledge of the pharmacokinetic interaction profile of metformin with organic cation transporter inhibitors, such as imatinib, is important to help develop safer more effective drug therapy with reduced side effects.
Interventions
- DRUG Metformin
- DRUG Imatinib
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 11 participants |
| Start Date | 2011-10 |
| Est. Completion | 2013-03 |
| Phase | Phase 1 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01404715
The ClinicalTrials.gov registry entry for NCT01404715 describes a study currently listed as completed, categorized as Phase 1. The registered enrollment target is 11 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Metformin is the first listed.
NCT01404715 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01404715 about?
NCT01404715 is a clinical study titled "Drug-drug Interaction Study With Metformin and Imatinib". This study will address the following question: Does imatinib influence the pharmacokinetics of metformin in healthy volunteers? Recent studies in the Giacomini laboratory have indicated that imatinib may block metformin elimination from the kidney by inhibiting organic cation transporter efflux of ...
What is the current status of trial NCT01404715?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 11 participants. The study started on 2011-10. Estimated completion is 2013-03.
What interventions are being tested in trial NCT01404715?
The interventions under investigation include: Metformin (DRUG), Imatinib (DRUG).
Who is sponsoring clinical trial NCT01404715?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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