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NCT01399944 · ClinicalTrials.gov registry record
The Molecular Basis for a Broad Range of Phenotypes Related to hTAS2R38
A clinical trial, sponsored by Monell Chemical Senses Center.
- Completed
- Registry status
- 70
- Enrollment target
NCT01399944: Completed study, sponsored by Monell Chemical Senses Center.
NCT01399944 is a clinical trial that has completed, run by Monell Chemical Senses Center. The registered enrollment target is 70 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01399944 has completed, sponsored by Monell Chemical Senses Center.
- COMPLETED
- Registry status
- 70 participants
- Enrollment target
Study Summary
This single-site, within-subject, experimental study is designed to test the hypothesis that individuals express taste receptors differently and have different sensitivities to bitter taste samples, which results from uneven expression. Subjects will include 100 racially and ethnically diverse, healthy adults. All subjects will provide saliva samples for genetic analysis and undergo taste testing with common psychophysical stimuli. From the pool of 100 subjects, 36 subjects from the common heterozygous group (PAV/AVI) and two from each homozygous group (AVI/AVI, nontaster and PAV/PAV, taster) will be invited to return for two additional sessions. During both sessions the investigators will 1) measure bitterness thresholds for PROP, a common psychophysical stimulus; 2) measure bitterness perception of several vegetables; 3) obtain a saliva sample and 4) collect taste papillae. The investigators will then isolate DNA and RNA from the taste papillae and isolate DNA from saliva to evaluate molecular differences over time and between individuals and how it relates to taste psychophysics. All psychophysical and cellular measurements will be done during both sessions so that the investigators can determine how much variation is observed over a one-week time period in both cellular phenotype and psychophysical phenotype.
Primary Outcome
Thresholds for propylthiouracil (PROP) will be measured using modified Harris-Kalmus recognition thresholds.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2011-07 |
| Est. Completion | 2013-06 |
What the finished NCT01399944 record still lists
NCT01399944 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 70 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01399944 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01399944 about?
NCT01399944 is a clinical study titled "The Molecular Basis for a Broad Range of Phenotypes Related to hTAS2R38". This single-site, within-subject, experimental study is designed to test the hypothesis that individuals express taste receptors differently and have different sensitivities to bitter taste samples, which results from uneven expression. Subjects will include 100 racially and ethnically diverse, heal...
What is the current status of trial NCT01399944?
This trial is currently completed. The enrollment target is 70 participants. The study started on 2011-07. Estimated completion is 2013-06.
Who is sponsoring clinical trial NCT01399944?
This trial is sponsored by Monell Chemical Senses Center, which has 16 total clinical trials registered on ClinicalTrials.gov.
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