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NCT01346124 · ClinicalTrials.gov registry record · NA
High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull
A NA study of Chordoma of Spine and Chordoma of Sacrum, sponsored by Massachusetts General Hospital.
- Active
- Registry status
- NA
- Development phase
- 64
- Enrollment target
- 2
- Study locations
NCT01346124: Active NA study of Chordoma of Spine and Chordoma of Sacrum, sponsored by Massachusetts General Hospital.
NCT01346124 is a NA study of Chordoma of Spine and Chordoma of Sacrum that is active but no longer recruiting, run by Massachusetts General Hospital. The registered enrollment target is 64 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower). The trial reports 2 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01346124, a NA study of Chordoma of Spine and Chordoma of Sacrum, is active but no longer recruiting, sponsored by Massachusetts General Hospital.
- ACTIVE NOT RECRUITING
- Registry status
- NA
- Development phase
- 64 participants
- Enrollment target
- 2
- Study locations
Study Summary
There are two types of external radiation treatments; proton beam and photon beam radiation. What type of therapy participants will receive will depend upon the location of their tumor. Standard treatment would involve receiving either proton or photon radiation delivered by a three dimensional (3-D) conformal radiation technique. 3-D conformal radiation therapy is a technique where the beams of radiation used in the treatment are shaped to match the tumor in order to avoid damaging the healthy surrounding tissue. Standard treatment also may include photon radiation delivered by intensity modulated (IMRT) technique. In this research study we are using an investigational technique to deliver proton radiation therapy called intensity modulated proton radiation treatment (IMPT) which is used to target cancer while sparing healthy tissue. With IMPT (and standard IMRT), radiation intensity can be turned down during the treatment. This control over the intensity of the radiation dose has the potential to provide accuracy and allows us to more safely increase the amount of radiation delivered to the tumor. This accuracy may potentially reduce side effects that patients would normally experience with 3-D proton radiation therapy. Surgery is often an important component of the treatment for these tumors and may be integrated with the IMPT.
Primary Outcome
To define the efficacy or high dose fractionated radiation alone or combined with surgery in achieving local tumor control in patients with base of skull chordomas and patients with spine/sacral chordomas or chondrosarcomas using intensity modulated photon and proton techniques.
Conditions Studied
Interventions
- RADIATION High Dose Intensity Modulated Proton Radiation
Study Locations (2)
Massachusetts
- Massachusetts General Hospital - Boston
Texas
- MD Anderson Cancer Center - Houston
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 64 participants |
| Start Date | 2012-12 |
| Est. Completion | 2027-12-31 |
| Phase | NA |
What the registry record for NCT01346124 still lists
NCT01346124 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 64 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (95% lower).
The record links to 5 conditions, with Chordoma of Spine appearing as the primary indexed condition, and to 1 intervention - of which High Dose Intensity Modulated Proton Radiation is the first listed.
NCT01346124 reports a single indexed study location in Massachusetts, Texas.
Frequently Asked Questions
What is clinical trial NCT01346124 about?
NCT01346124 is a clinical study titled "High Dose Intensity Modulated Proton Radiation Treatment +/- Surgical Resection of Sarcomas of the Spine, Sacrum and Base of Skull". There are two types of external radiation treatments; proton beam and photon beam radiation. What type of therapy participants will receive will depend upon the location of their tumor. Standard treatment would involve receiving either proton or photon radiation delivered by a three dimensional (3-D...
What is the current status of trial NCT01346124?
This trial is currently active not recruiting. It is a NA study. The enrollment target is 64 participants. The study started on 2012-12. Estimated completion is 2027-12-31.
What conditions does trial NCT01346124 study?
This clinical trial studies the following conditions: Chordoma of Spine, Chordoma of Sacrum, Chordoma of Base of Skull, Chondrosarcoma of the Spine, Chondrosarcoma of the Sacrum.
What interventions are being tested in trial NCT01346124?
The interventions under investigation include: High Dose Intensity Modulated Proton Radiation (RADIATION).
Who is sponsoring clinical trial NCT01346124?
This trial is sponsored by Massachusetts General Hospital, which has 2,032 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01346124 being conducted?
This trial has 2 study locations across Massachusetts, Texas. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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Where NCT01346124's enrollment target sits among peer trials
64 1147th of 2000 higher than 844 of 2,000 other NA trials
participants (enrollment target), bucketed by value
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Source ClinicalTrials.gov registry export · 2026-08-08
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