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NCT01333956 · ClinicalTrials.gov registry record · Phase 1
Effects of Pregabalin on Pain After Total Knee Arthroplasty
A Phase 1 study of Primary Total Knee Arthroplasty, sponsored by Hospital for Special Surgery, New York.
- Completed
- Registry status
- Phase 1
- Development phase
- 120
- Enrollment target
- 1
- Study location
NCT01333956: Completed Phase 1 study of Primary Total Knee Arthroplasty, sponsored by Hospital for Special Surgery, New York.
NCT01333956 is a Phase 1 study of Primary Total Knee Arthroplasty that has completed, run by Hospital for Special Surgery, New York. The registered enrollment target is 120 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (100% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01333956, a Phase 1 study of Primary Total Knee Arthroplasty, has completed, sponsored by Hospital for Special Surgery, New York.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 120 participants
- Enrollment target
- 1
- Study location
Study Summary
Total knee arthroplasty can cause severe postoperative pain, and patients typically receive oral opioid analgesics for over 2 weeks. Side effects of pain management may impair participation in physical therapy and diminish patient satisfaction. Anecdotally, it seems that pregabalin is very helpful to patients after total knee arthroplasty. However, pregabalin can have side effects. It is not clear how much pregabalin to prescribe. Low doses may not be effective, but use of high doses may increase the incidence and severity of side effects.The purpose of this study is to determine which dosage of pregabalin is the most effective at reducing pain after knee surgery.
Primary Outcome
Pain assessment scale (Numeric Rating Scale) (0=no pain; 10=worst pain imaginable).
Conditions Studied
Interventions
- DRUG Placebo
- DRUG Pregabalin 100mg
- DRUG Pregabalin 50mg
- DRUG Pregabalin 150mg
Study Locations (1)
New York
- Hospital for Special Surgery - New York
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2011-05 |
| Est. Completion | 2013-06 |
| Phase | Phase 1 |
What the finished NCT01333956 record still lists
NCT01333956 is an interventional study that assigns participants to a tested intervention. The registered 120 participants enrollment target is mid-sized for trials with a published cap, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (100% higher).
The record links to 1 condition, with Primary Total Knee Arthroplasty appearing as the primary indexed condition, and to 4 interventions - of which Placebo is the first listed.
NCT01333956 reports a single indexed study location in New York.
Frequently Asked Questions
What is clinical trial NCT01333956 about?
NCT01333956 is a clinical study titled "Effects of Pregabalin on Pain After Total Knee Arthroplasty". Total knee arthroplasty can cause severe postoperative pain, and patients typically receive oral opioid analgesics for over 2 weeks. Side effects of pain management may impair participation in physical therapy and diminish patient satisfaction. Anecdotally, it seems that pregabalin is very helpful t...
What is the current status of trial NCT01333956?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 120 participants. The study started on 2011-05. Estimated completion is 2013-06.
What conditions does trial NCT01333956 study?
This clinical trial studies the following conditions: Primary Total Knee Arthroplasty.
What interventions are being tested in trial NCT01333956?
The interventions under investigation include: Placebo (DRUG), Pregabalin 100mg (DRUG), Pregabalin 50mg (DRUG), Pregabalin 150mg (DRUG).
Who is sponsoring clinical trial NCT01333956?
This trial is sponsored by Hospital for Special Surgery, New York, which has 194 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01333956 being conducted?
This trial has 1 study location across New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01333956's enrollment target sits among peer trials
120 479th of 2000 higher than 1,503 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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