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NCT01330719 · ClinicalTrials.gov registry record · NA
Mechanisms and Treatment Response of Aggressive Periodontitis in Children
A NA study of Aggressive Periodontitis, sponsored by University of Florida.
- Completed
- Registry status
- NA
- Development phase
- 514
- Enrollment target
- 10
- Study locations
NCT01330719: Completed NA study of Aggressive Periodontitis, sponsored by University of Florida.
NCT01330719 is a NA study of Aggressive Periodontitis that has completed, run by University of Florida. The registered enrollment target is 514 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (63% lower). The trial reports 10 study locations across 2 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01330719, a NA study of Aggressive Periodontitis, has completed, sponsored by University of Florida.
- COMPLETED
- Registry status
- NA
- Development phase
- 514 participants
- Enrollment target
- 10
- Study locations
Study Summary
Although of low prevalence, aggressive periodontitis is a rapid destructive form of periodontal disease that initiates at a young age, leading to premature loss of first molars and incisors. Little is known on the mechanisms of this disease. It is imperative to understand mechanisms of disease to establish proper treatment. We have established a controlled study in a comparable population presenting similar aggressive disease characteristics to evaluate the mechanisms of this disease. It is the goal of this study to determine immunological and microbiological mechanisms responsible for the rapid tissue destruction in children with localized aggressive periodontitis and how traditional periodontal intervention affects these mechanisms. Important knowledge gained with this proposal will aid in defining specific treatment approaches to better control disease progression and prevent disease initiation in susceptible individuals.
Primary Outcome
The investigators are doing analysis of single nucleotide polymorphisms (DNA sequence variation) and methylation (addition of a methyl group) of DNA of specific genes related to inflammation.
Conditions Studied
Interventions
- PROCEDURE Diseased periodontal treatment
- PROCEDURE Conventional periodontal treatment
Study Locations (10)
Florida
- Acorn Dental Clinic - Brooker
- Broward College - Fort Lauderdale
- Dental Clinical Research Unit, University of Florida - Gainesville
- Azalea Dental Clinic - Gainesville
- UF Hialeah Dental Clinic - Hialeah
- Duval County Department of Health - Jacksonville
- UF Naples Pediatric Dental Clinic - Naples
- Gadsden County Health Department--Quincy Dental Clinic - Quincy
- Leon County Health Department - Tallahassee
Kentucky
- University of Kentucky - Lexington
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 514 participants |
| Start Date | 2006-12 |
| Est. Completion | 2022-12-02 |
| Phase | NA |
What the finished NCT01330719 record still lists
NCT01330719 is an interventional study that assigns participants to a tested intervention. The registered 514 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (63% lower).
The record links to 1 condition, with Aggressive Periodontitis appearing as the primary indexed condition, and to 2 interventions - of which Diseased periodontal treatment is the first listed.
NCT01330719 lists 10 locations in 2 states (Florida, Kentucky).
Frequently Asked Questions
What is clinical trial NCT01330719 about?
NCT01330719 is a clinical study titled "Mechanisms and Treatment Response of Aggressive Periodontitis in Children". Although of low prevalence, aggressive periodontitis is a rapid destructive form of periodontal disease that initiates at a young age, leading to premature loss of first molars and incisors. Little is known on the mechanisms of this disease. It is imperative to understand mechanisms of disease to es...
What is the current status of trial NCT01330719?
This trial is currently completed. It is a NA study. The enrollment target is 514 participants. The study started on 2006-12. Estimated completion is 2022-12-02.
What conditions does trial NCT01330719 study?
This clinical trial studies the following conditions: Aggressive Periodontitis.
What interventions are being tested in trial NCT01330719?
The interventions under investigation include: Diseased periodontal treatment (PROCEDURE), Conventional periodontal treatment (PROCEDURE).
Who is sponsoring clinical trial NCT01330719?
This trial is sponsored by University of Florida, which has 1,106 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT01330719 being conducted?
This trial has 10 study locations across Florida, Kentucky. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01330719's enrollment target sits among peer trials
514 192nd of 2000 higher than 1,809 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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