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NCT01274429 · ClinicalTrials.gov registry record · Phase 1
Peanut Oral Immunotherapy (OIT) - Initial Pilot Study in Adults
A Phase 1 study, sponsored by University of North Carolina, Chapel Hill.
- Terminated
- Registry status
- Phase 1
- Development phase
- 5
- Enrollment target
NCT01274429: Clinical Trial Phase 1 study, sponsored by University of North Carolina, Chapel Hill.
NCT01274429 is a Phase 1 study that was terminated before completion, run by University of North Carolina, Chapel Hill. The registered enrollment target is 5 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01274429, a Phase 1 study, was terminated before completion, sponsored by University of North Carolina, Chapel Hill.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 5 participants
- Enrollment target
Study Summary
The goal of this study is to produce a new treatment that would benefit adult subjects by lowering the risk of anaphylactic reactions (desensitization), and changing the peanut-specific immune response in subjects who have peanut allergy (tolerance). This project is designed to study the innovative idea that oral immunotherapy (OIT), the ingestion of small increasing amounts of food allergen, will desensitize subjects with peanut hypersensitivity by regulating their mucosal and systemic immune reactivity and cause long-term tolerance.
Primary Outcome
Assess mg of peanut tolerated on double-blind placebo-controlled food challenge as a measure of desensitization and tolerance
Interventions
- DRUG Peanut flour
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2010-12 |
| Est. Completion | 2015-11 |
| Phase | Phase 1 |
Why NCT01274429 stopped before completion
NCT01274429 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 5 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (92% lower).
The record links to 0 conditions, and to 1 intervention - of which Peanut flour is the first listed.
NCT01274429 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01274429 about?
NCT01274429 is a clinical study titled "Peanut Oral Immunotherapy (OIT) - Initial Pilot Study in Adults". The goal of this study is to produce a new treatment that would benefit adult subjects by lowering the risk of anaphylactic reactions (desensitization), and changing the peanut-specific immune response in subjects who have peanut allergy (tolerance). This project is designed to study the innovative ...
What is the current status of trial NCT01274429?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 5 participants. The study started on 2010-12. Estimated completion is 2015-11.
What interventions are being tested in trial NCT01274429?
The interventions under investigation include: Peanut flour (DRUG).
Who is sponsoring clinical trial NCT01274429?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01274429's enrollment target sits among peer trials
5 1989th of 2000 higher than 6 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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