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NCT01271491 · ClinicalTrials.gov registry record
The Genetics of Respiratory Failure in Bronchiolitis
A clinical trial, sponsored by Connecticut Children's Medical Center.
- Completed
- Registry status
- 174
- Enrollment target
NCT01271491: Completed study, sponsored by Connecticut Children's Medical Center.
NCT01271491 is a clinical trial that has completed, run by Connecticut Children's Medical Center. The registered enrollment target is 174 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01271491 has completed, sponsored by Connecticut Children's Medical Center.
- COMPLETED
- Registry status
- 174 participants
- Enrollment target
Study Summary
Bronchiolitis is a potentially severe infection of the airway in infants and children, and among the most frequent diagnoses leading to pediatric intensive care unit admission in infants. This acute infection is caused by an array of viruses, but respiratory syncytial virus (RSV) is the most frequently implicated. The majority of infants hospitalized with bronchiolitis are previously healthy, and half of infants intubated and mechanically ventilated for respiratory failure due to RSV bronchiolitis have no previously identified risk factors. It is likely, therefore, that other factors, particularly genetic heterogeneity of the host, contribute to disease severity. However, no previous study has investigated the association of genetic variants with respiratory failure in children with bronchiolitis. Several categories of candidate genes have emerged as potentially important in the pathogenesis of the disease. Specifically, genetic polymorphisms of surfactants, pattern recognition receptors, receptor adhesion molecules, and cytokines have been examined. The aim is to evaluate these polymorphisms to determine their association with respiratory failure in a cohort of more severely ill children with bronchiolitis.
Primary Outcome
The primary end point is respiratory failure.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 174 participants |
| Start Date | 2010-11 |
| Est. Completion | 2018-10 |
What the finished NCT01271491 record still lists
NCT01271491 is an observational study that tracks outcomes without assigning an intervention. The registered 174 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT01271491 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01271491 about?
NCT01271491 is a clinical study titled "The Genetics of Respiratory Failure in Bronchiolitis". Bronchiolitis is a potentially severe infection of the airway in infants and children, and among the most frequent diagnoses leading to pediatric intensive care unit admission in infants. This acute infection is caused by an array of viruses, but respiratory syncytial virus (RSV) is the most frequen...
What is the current status of trial NCT01271491?
This trial is currently completed. The enrollment target is 174 participants. The study started on 2010-11. Estimated completion is 2018-10.
Who is sponsoring clinical trial NCT01271491?
This trial is sponsored by Connecticut Children's Medical Center, which has 55 total clinical trials registered on ClinicalTrials.gov.
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