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COMPLETED Phase 2

Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer

NCT01266447 · View on ClinicalTrials.gov ↗

Study Summary

This phase II clinical trial is studying the how well veliparib, topotecan hydrochloride, and filgrastim or pegfilgrastim work in treating patients with persistent or recurrent cervical cancer. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs used in chemotherapy, such as topotecan hydrochloride, work in different ways to stop the growth of tumor cells, either by killing the cells or by blocking them from dividing. Giving veliparib with chemotherapy may kill more tumor cells. Filgrastim or pegfilgrastim may cause the body to make more blood cells and help it recover from the side effects of chemotherapy.

Interventions

  • OTHER Laboratory Biomarker Analysis
  • BIOLOGICAL Filgrastim
  • BIOLOGICAL Pegfilgrastim
  • DRUG Veliparib
  • DRUG Topotecan Hydrochloride

Study Locations (20)

Michigan

  • Saint Joseph Mercy Hospital — Ann Arbor
  • Michigan Cancer Research Consortium CCOP — Ann Arbor
  • Oakwood Hospital and Medical Center — Dearborn
  • Saint John Hospital and Medical Center — Detroit
  • Hurley Medical Center — Flint
  • Genesys Regional Medical Center — Grand Blanc
  • Allegiance Health — Jackson

Illinois

  • Decatur Memorial Hospital — Decatur
  • Sudarshan K Sharma MD Limted-Gynecologic Oncology — Hinsdale
  • Memorial Medical Center — Springfield

Connecticut

  • Smilow Cancer Hospital Care Center at Saint Francis — Hartford
  • The Hospital of Central Connecticut — New Britain

California

  • UC Irvine Health/Chao Family Comprehensive Cancer Center — Orange

Colorado

  • University of Colorado Cancer Center - Anschutz Cancer Pavilion — Aurora

Florida

  • Florida Hospital Orlando — Orlando

Georgia

  • Memorial University Medical Center — Savannah

Idaho

  • Saint Alphonsus Cancer Care Center-Boise — Boise

Trial Details

FieldValue
Enrollment Target 27 participants
Start Date 2011-02
Est. Completion 2016-01
Phase Phase 2

Sponsor

National Cancer Institute (NCI)

2,390 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT01266447

The ClinicalTrials.gov registry entry for NCT01266447 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 27 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is National Cancer Institute (NCI), which has 2,390 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 8 conditions, with Cervical Squamous Cell Carcinoma appearing as the primary indexed condition, and to 5 interventions — of which Laboratory Biomarker Analysis is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT01266447 reports 20 study locations spanning 11 distinct geographic areas — top geographies include Michigan, Illinois, Connecticut. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT01266447 about?

NCT01266447 is a clinical study titled "Veliparib, Topotecan Hydrochloride, and Filgrastim or Pegfilgrastim in Treating Patients With Persistent or Recurrent Cervical Cancer". This phase II clinical trial is studying the how well veliparib, topotecan hydrochloride, and filgrastim or pegfilgrastim work in treating patients with persistent or recurrent cervical cancer. Veliparib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth. Drugs...

What is the current status of trial NCT01266447?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 27 participants. The study started on 2011-02. Estimated completion is 2016-01.

What conditions does trial NCT01266447 study?

This clinical trial studies the following conditions: Cervical Squamous Cell Carcinoma, Cervical Adenocarcinoma, Cervical Adenosquamous Carcinoma, Recurrent Cervical Carcinoma, Cervical Small Cell Carcinoma. These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT01266447?

The interventions under investigation include: Laboratory Biomarker Analysis (OTHER), Filgrastim (BIOLOGICAL), Pegfilgrastim (BIOLOGICAL), Veliparib (DRUG), Topotecan Hydrochloride (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT01266447?

This trial is sponsored by National Cancer Institute (NCI), which has 2,390 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT01266447 being conducted?

This trial has 20 study locations across California, Colorado, Connecticut, Florida, Georgia. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial