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NCT01229514 · ClinicalTrials.gov registry record
Functional Magnetic Resonance Imaging (fMRI) Findings in Children With Early Exposure to General Anesthesia
A clinical trial, sponsored by Nationwide Children's Hospital.
- Completed
- Registry status
- 30
- Enrollment target
NCT01229514: Completed study, sponsored by Nationwide Children's Hospital.
NCT01229514 is a clinical trial that has completed, run by Nationwide Children's Hospital. The registered enrollment target is 30 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01229514 has completed, sponsored by Nationwide Children's Hospital.
- COMPLETED
- Registry status
- 30 participants
- Enrollment target
Study Summary
General anesthetic medications have been shown to cause neuronal cell death in the brains of infant rodents. Ethanol and general anesthetics both act on NMDA and GABA receptors,and appear to have similar mechanisms of toxicity in the immature rodent brain. Functional MRI (fMRI) is a technique developed for mapping brain activation and has been utilized to examine how the brains of children with a history of early exposure to ethanol function differently from children without such a history. This study will utilize fMRI to look for specific changes in brain activation patterns in children with a history of early exposure to general anesthesia, as compared to children without such exposure.
Primary Outcome
To evaluate the use of fMRI as a tool to investigate the functional consequence of exposure to general anesthetic medications during early brain development
Interventions
- OTHER fMRI
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 30 participants |
| Start Date | 2008-10 |
| Est. Completion | 2011-06 |
What the finished NCT01229514 record still lists
NCT01229514 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 30 participants, a relatively small participant target.
The record links to 0 conditions, and to 1 intervention - of which fMRI is the first listed.
NCT01229514 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01229514 about?
NCT01229514 is a clinical study titled "Functional Magnetic Resonance Imaging (fMRI) Findings in Children With Early Exposure to General Anesthesia". General anesthetic medications have been shown to cause neuronal cell death in the brains of infant rodents. Ethanol and general anesthetics both act on NMDA and GABA receptors,and appear to have similar mechanisms of toxicity in the immature rodent brain. Functional MRI (fMRI) is a technique develo...
What is the current status of trial NCT01229514?
This trial is currently completed. The enrollment target is 30 participants. The study started on 2008-10. Estimated completion is 2011-06.
What interventions are being tested in trial NCT01229514?
The interventions under investigation include: fMRI (OTHER).
Who is sponsoring clinical trial NCT01229514?
This trial is sponsored by Nationwide Children's Hospital, which has 188 total clinical trials registered on ClinicalTrials.gov.
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