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NCT01227954 · ClinicalTrials.gov registry record · Phase 2
Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases
A Phase 2 study, sponsored by Radiation Therapy Oncology Group.
- Completed
- Registry status
- Phase 2
- Development phase
- 113
- Enrollment target
NCT01227954: Completed Phase 2 study, sponsored by Radiation Therapy Oncology Group.
NCT01227954 is a Phase 2 study that has completed, run by Radiation Therapy Oncology Group. The registered enrollment target is 113 participants, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (15% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01227954, a Phase 2 study, has completed, sponsored by Radiation Therapy Oncology Group.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 113 participants
- Enrollment target
Study Summary
RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. PURPOSE: This phase II trial is studying how well avoiding the hippocampus during whole-brain radiation therapy works in treating patients with brain metastases.
Primary Outcome
Change in Hopkins Verbal Learning Test-Revised delayed recall (HVLT\_R DR) score from baseline to 4 months after the start of treatment calculated as (baseline score - 4 month score)/ baseline score. A positive change indicates a decline in function. The HVLT-R assesses verbal learning and memory. It incorporates 6 different forms, helping to mitigate practice effects of repeated administrations. Each form includes 12 nouns (targets) with 4 words drawn from 3 semantic categories, which differ ac
Interventions
- RADIATION intensity-modulated radiation therapy
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 113 participants |
| Start Date | 2011-03 |
| Est. Completion | 2016-12 |
| Phase | Phase 2 |
What the finished NCT01227954 record still lists
NCT01227954 is an interventional study that assigns participants to a tested intervention. The registered 113 participants enrollment target is mid-sized for trials with a published cap, below the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (15% lower).
The record links to 0 conditions, and to 1 intervention - of which intensity-modulated radiation therapy is the first listed.
NCT01227954 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01227954 about?
NCT01227954 is a clinical study titled "Avoiding the Hippocampus During Whole-Brain Radiation Therapy in Treating Patients With Brain Metastases". RATIONALE: Radiation therapy uses high energy x-rays to kill tumor cells. PURPOSE: This phase II trial is studying how well avoiding the hippocampus during whole-brain radiation therapy works in treating patients with brain metastases.
What is the current status of trial NCT01227954?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 113 participants. The study started on 2011-03. Estimated completion is 2016-12.
What interventions are being tested in trial NCT01227954?
The interventions under investigation include: intensity-modulated radiation therapy (RADIATION).
Who is sponsoring clinical trial NCT01227954?
This trial is sponsored by Radiation Therapy Oncology Group, which has 144 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01227954's enrollment target sits among peer trials
113 631st of 2000 higher than 1,370 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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