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NCT01208324 · ClinicalTrials.gov registry record · NA
Estrogen and Serotonin on Changing Brain Chemistry
A NA study, sponsored by University of Colorado, Denver.
- Completed
- Registry status
- NA
- Development phase
- 47
- Enrollment target
NCT01208324: Completed NA study, sponsored by University of Colorado, Denver.
NCT01208324 is a NA study that has completed, run by University of Colorado, Denver. The registered enrollment target is 47 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01208324, a NA study, has completed, sponsored by University of Colorado, Denver.
- COMPLETED
- Registry status
- NA
- Development phase
- 47 participants
- Enrollment target
Study Summary
The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation. The investigators will study the effects of acute tryptophan (TRP) depletion on cognition and mood in healthy menopausal women before and after estrogen replacement treatment (ERT). Using functional magnetic resonance imaging (fMRI), the investigators will identify differences in brain activation during memory tasks with and without TRP depletion and before and after estrogen therapy in order to determine which brain regions and cognitive functions are affected by each manipulation.
Primary Outcome
To replicate and extend our previous behavioral findings of an interaction between estrogen therapy (ET) and tryptophan depletion on verbal memory in a group of early menopausal women randomized to receive ET. Blood-oxygen-level dependent or BOLD signal is the outcome of BOLD imaging, which is a technique used in functional MRI. BOLD signal reflects changes in regional cerebral blood flow which delineate regional activity. A positive BOLD signal marks an increase in regional blood flow, while a
Interventions
- DRUG Placebo Patch
- DRUG Placebo pills
- DRUG Amino acids
- DRUG estrogen patch
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 47 participants |
| Start Date | 2010-03-04 |
| Est. Completion | 2018-11 |
| Phase | NA |
What the finished NCT01208324 record still lists
NCT01208324 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 47 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 4 interventions - of which Placebo Patch is the first listed.
NCT01208324 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01208324 about?
NCT01208324 is a clinical study titled "Estrogen and Serotonin on Changing Brain Chemistry". The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation. The investigators will study the effects of acute tryptophan (TRP) depletion on cognition and mood in healthy menopausal women before and after estrogen replacement tre...
What is the current status of trial NCT01208324?
This trial is currently completed. It is a NA study. The enrollment target is 47 participants. The study started on 2010-03-04. Estimated completion is 2018-11.
What interventions are being tested in trial NCT01208324?
The interventions under investigation include: Placebo Patch (DRUG), Placebo pills (DRUG), Amino acids (DRUG), estrogen patch (DRUG).
Who is sponsoring clinical trial NCT01208324?
This trial is sponsored by University of Colorado, Denver, which has 1,283 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01208324's enrollment target sits among peer trials
47 1400th of 2000 higher than 599 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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