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NCT01183559 · ClinicalTrials.gov registry record · Phase 1
A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery
A Phase 1 study, sponsored by Fox Chase Cancer Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
NCT01183559: Completed Phase 1 study, sponsored by Fox Chase Cancer Center.
NCT01183559 is a Phase 1 study that has completed, run by Fox Chase Cancer Center. The registered enrollment target is 9 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01183559, a Phase 1 study, has completed, sponsored by Fox Chase Cancer Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
Study Summary
The purpose of the study is to determine the most tolerable and safe dose of ZD6474 (Zactima, Vandetanib) when given with standard chemotherapy, radiation therapy and surgery in patients with cancer of the esophagus
Primary Outcome
To determine the maximum tolerated dose (MTD) of Vandetanib given concurrently with chemotherapy and radiation therapy followed by surgery (esophagectomy)evaluated by the frequency, severity and duration of adverse events that occur during treatment and for four weeks following surgery as measured by serial blood tests, electrocardiograms and physical assessments
Interventions
- DRUG Carboplatin
- DRUG Paclitaxel
- DRUG Vandetanib
- DRUG 5 Fluorouracil (FU)
- RADIATION External Beam Radiation Therapy (RT)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 2008-08-07 |
| Est. Completion | 2011-08 |
| Phase | Phase 1 |
What the finished NCT01183559 record still lists
NCT01183559 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 5 interventions - of which Carboplatin is the first listed.
NCT01183559 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01183559 about?
NCT01183559 is a clinical study titled "A Trial of ZD6474, Paclitaxel, Carboplatin, 5-Fluorouracil, and Radiation Therapy Followed by Surgery". The purpose of the study is to determine the most tolerable and safe dose of ZD6474 (Zactima, Vandetanib) when given with standard chemotherapy, radiation therapy and surgery in patients with cancer of the esophagus
What is the current status of trial NCT01183559?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 2008-08-07. Estimated completion is 2011-08.
What interventions are being tested in trial NCT01183559?
The interventions under investigation include: Carboplatin (DRUG), Paclitaxel (DRUG), Vandetanib (DRUG), 5 Fluorouracil (FU) (DRUG), External Beam Radiation Therapy (RT) (RADIATION).
Who is sponsoring clinical trial NCT01183559?
This trial is sponsored by Fox Chase Cancer Center, which has 183 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01183559's enrollment target sits among peer trials
9 1955th of 2000 higher than 42 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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