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NCT01137721 · ClinicalTrials.gov registry record
State Of The Art Functional Imaging In Sickle Cell Disease
A clinical trial, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 38
- Enrollment target
NCT01137721: Completed study, sponsored by St. Jude Children's Research Hospital.
NCT01137721 is a clinical trial that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 38 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01137721 has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 38 participants
- Enrollment target
Study Summary
Sickle cell anemia (SCA) is a serious blood disease with blood vessel changes leading to brain injury and stroke. Studies show about 11% of patients with SCA will develop obvious stroke before age 20 years, with children less than 10 years of age especially vulnerable. The main objective of the SCDMR4\[State Of The Art Functional Imaging In Sickle Cell Disease\] trial is to compare the gray matter cerebral blood flow, measured by MRI,\[magnetic resonance imaging\] ASL \[Arterial Spin Labeling\] perfusion before treatment begins and after the appropriate hydroxyurea dosage is reached (\~ one year). Other important objectives of the SCDMR4 trial include describing the effect of hydroxyurea therapy and transfusion therapy on the functional MRI response, diffusion tensor imaging of white matter, brain function, and transcranial Doppler blood velocities.
Primary Outcome
Change in gray matter cerebral blood flow measured by arterial spin labeling techniques from before (baseline) to after reaching a stable hydroxyurea maximum tolerated dose.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 38 participants |
| Start Date | 2010-09 |
| Est. Completion | 2016-06 |
What the finished NCT01137721 record still lists
NCT01137721 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 38 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01137721 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01137721 about?
NCT01137721 is a clinical study titled "State Of The Art Functional Imaging In Sickle Cell Disease". Sickle cell anemia (SCA) is a serious blood disease with blood vessel changes leading to brain injury and stroke. Studies show about 11% of patients with SCA will develop obvious stroke before age 20 years, with children less than 10 years of age especially vulnerable. The main objective of the SCDM...
What is the current status of trial NCT01137721?
This trial is currently completed. The enrollment target is 38 participants. The study started on 2010-09. Estimated completion is 2016-06.
Who is sponsoring clinical trial NCT01137721?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
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