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NCT01132846 · ClinicalTrials.gov registry record · Phase 2
Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study
A Phase 2 study, sponsored by Duke University.
- Completed
- Registry status
- Phase 2
- Development phase
- 360
- Enrollment target
NCT01132846: Completed Phase 2 study, sponsored by Duke University.
NCT01132846 is a Phase 2 study that has completed, run by Duke University. The registered enrollment target is 360 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (171% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01132846, a Phase 2 study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 360 participants
- Enrollment target
Study Summary
The purpose of this study is to determine the benefits and safety of intravenous administration of low dose nesiritide or low dose dopamine in patients with congestive heart failure and kidney dysfunction. There is a substudy in a subset of subjects that is being used to determine whether the Provocative Dyspnea Severity Score (pDSS) is a more sensitive index of variability in clinical status than the dyspnea VAS assessed without standardization of conditions at assessments.
Primary Outcome
The primary Safety endpoint is change in serum cystatin C from randomization to 72 hours.
Interventions
- OTHER Placebo
- DRUG Dopamine
- DRUG Nesiritide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 360 participants |
| Start Date | 2010-08 |
| Est. Completion | 2013-06 |
| Phase | Phase 2 |
What the finished NCT01132846 record still lists
NCT01132846 is an interventional study that assigns participants to a tested intervention. The registered 360 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (171% higher).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT01132846 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01132846 about?
NCT01132846 is a clinical study titled "Renal Optimization Strategies Evaluation in Acute Heart Failure and Reliable Evaluation of Dyspnea in the Heart Failure Network (ROSE) Study". The purpose of this study is to determine the benefits and safety of intravenous administration of low dose nesiritide or low dose dopamine in patients with congestive heart failure and kidney dysfunction. There is a substudy in a subset of subjects that is being used to determine whether the Provoc...
What is the current status of trial NCT01132846?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 360 participants. The study started on 2010-08. Estimated completion is 2013-06.
What interventions are being tested in trial NCT01132846?
The interventions under investigation include: Placebo (OTHER), Dopamine (DRUG), Nesiritide (DRUG).
Who is sponsoring clinical trial NCT01132846?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01132846's enrollment target sits among peer trials
360 123rd of 2000 higher than 1,874 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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