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NCT01123668 · ClinicalTrials.gov registry record
Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 101
- Enrollment target
NCT01123668: Completed study, sponsored by Duke University.
NCT01123668 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 101 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01123668 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 101 participants
- Enrollment target
Study Summary
The purpose of this study is to evaluate how nicotine, withdrawal from nicotine, and methylphenidate (a drug used for the treatment of ADHD) affect the brain of smokers with and without ADHD while doing tasks in an functional Magnetic Resonance Imaging scanner. Study Hypotheses: 1. compared to non-ADHD smokers, smokers with ADHD will exhibit greater abstinence-induced decrements in response inhibition performance and reward and greater concomitant disruptions of brain activity 2. administration of MPH to abstinent smokers will ameliorate response inhibition performance and reward deficits and task-related brain activation and this effect will be greater among ADHD smokers 3. genetic markers of dopamine neurotransmission will moderate abstinence- and MPH - induced changes in task-related brain activation across tasks.
Primary Outcome
Smokers will undergo three functional Magnetic Resonance Image scanning sessions while performing a task that measures response inhibition (Go/Go/No-Go task) Scanning will take place in the following conditions: smoking as usual + placebo pill, 24 hr smoking abstinence + placebo pill and 24 hr abstinence + methylphenidate (MPH). Methylphenidate is a dopamine reuptake inhibitor and its administration will allow us to evaluate the role of dopamine neurotransmission on response inhibition in the co
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 101 participants |
| Start Date | 2009-07 |
| Est. Completion | 2014-08 |
What the finished NCT01123668 record still lists
NCT01123668 is an observational study that tracks outcomes without assigning an intervention. The registered 101 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 0 interventions.
NCT01123668 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01123668 about?
NCT01123668 is a clinical study titled "Neuroimaging of Smokers With and Without Attention Deficit Hyperactivity Disorder (ADHD)". The purpose of this study is to evaluate how nicotine, withdrawal from nicotine, and methylphenidate (a drug used for the treatment of ADHD) affect the brain of smokers with and without ADHD while doing tasks in an functional Magnetic Resonance Imaging scanner. Study Hypotheses: 1. compared to non...
What is the current status of trial NCT01123668?
This trial is currently completed. The enrollment target is 101 participants. The study started on 2009-07. Estimated completion is 2014-08.
Who is sponsoring clinical trial NCT01123668?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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