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NCT01072916 · ClinicalTrials.gov registry record
Serine Proteases in Gastrointestinal Function and Irritable Bowel Syndrome (IBS)
A clinical trial, sponsored by University of North Carolina, Chapel Hill.
- Completed
- Registry status
- 60
- Enrollment target
NCT01072916: Completed study, sponsored by University of North Carolina, Chapel Hill.
NCT01072916 is a clinical trial that has completed, run by University of North Carolina, Chapel Hill. The registered enrollment target is 60 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01072916 has completed, sponsored by University of North Carolina, Chapel Hill.
- COMPLETED
- Registry status
- 60 participants
- Enrollment target
Study Summary
The proposed pilot project for this seed grant focuses on the role of intestinal serine-proteases in the pathogenesis of diarrhea-predominant IBS (D-IBS). In this study we will further assess serine-protease activity in patients with D-IBS and also explore a possible mechanism by which these proteases can lead to alterations in intestinal physiology and symptoms in these patients. The general hypotheses for the proposed research are that (A) the levels of fecal serine-protease in patients with D-IBS are abnormally increased (B) this abnormal serine-protease activity leads to/is associated with an abnormal increase in intestinal permeability and therefore enables (C) chronic stimulation and activation of the mucosal immune system in these patients. In addition, it is aim to determine whither periodontal inflammation is associated with intestinal permeability and serine protease activity.
Primary Outcome
we will use an elisa-based method to measure the activity of serine proteases in fecal samples from IBS and HC subjects
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 60 participants |
| Start Date | 2009-02 |
| Est. Completion | 2015-12 |
What the finished NCT01072916 record still lists
NCT01072916 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 60 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT01072916 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01072916 about?
NCT01072916 is a clinical study titled "Serine Proteases in Gastrointestinal Function and Irritable Bowel Syndrome (IBS)". The proposed pilot project for this seed grant focuses on the role of intestinal serine-proteases in the pathogenesis of diarrhea-predominant IBS (D-IBS). In this study we will further assess serine-protease activity in patients with D-IBS and also explore a possible mechanism by which these proteas...
What is the current status of trial NCT01072916?
This trial is currently completed. The enrollment target is 60 participants. The study started on 2009-02. Estimated completion is 2015-12.
Who is sponsoring clinical trial NCT01072916?
This trial is sponsored by University of North Carolina, Chapel Hill, which has 1,109 total clinical trials registered on ClinicalTrials.gov.
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