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NCT01059994 · ClinicalTrials.gov registry record · NA
Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability
A NA study, sponsored by The University of Texas Medical Branch, Galveston.
- Completed
- Registry status
- NA
- Development phase
- 12
- Enrollment target
NCT01059994: Completed NA study, sponsored by The University of Texas Medical Branch, Galveston.
NCT01059994 is a NA study that has completed, run by The University of Texas Medical Branch, Galveston. The registered enrollment target is 12 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01059994, a NA study, has completed, sponsored by The University of Texas Medical Branch, Galveston.
- COMPLETED
- Registry status
- NA
- Development phase
- 12 participants
- Enrollment target
Study Summary
This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older individuals. We propose to test a new method that may enable simultaneous determination of both vascular and skeletal muscle NO production for the first time in humans. Further, we will determine whether augmentation of NO-mediated responses, by administration of sildenafil citrate (Viagra), reduces fatigue and fatigability in older individuals.
Primary Outcome
Muscle fatigue was tested before and after 1 week of placebo/sildenafil (25mg/day) treatment. Subjects were asked to perform maximum effort isokinetic knee extensions until force production reached 50% of their MVC (maximum voluntary contraction). Data was collected as number of successful repetitions completed between start and 50% MVC. Data is presented as percent change in repetitions (1 week of treatment / baseline).
Interventions
- DRUG Sildenafil
- DRUG Placebo sildenafil
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2010-01 |
| Est. Completion | 2013-07 |
| Phase | NA |
What the finished NCT01059994 record still lists
NCT01059994 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (99% lower).
The record links to 0 conditions, and to 2 interventions - of which Sildenafil is the first listed.
NCT01059994 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01059994 about?
NCT01059994 is a clinical study titled "Role of Skeletal Muscle Nitric Oxide Production in Age-related Fatigue and Fatigability". This is a pilot study funded by the National Institutes of Health. In this project, we will investigate the potential effect of skeletal muscle nitric oxide (NO) production on muscle strength and physical function in older individuals. We propose to test a new method that may enable simultaneous det...
What is the current status of trial NCT01059994?
This trial is currently completed. It is a NA study. The enrollment target is 12 participants. The study started on 2010-01. Estimated completion is 2013-07.
What interventions are being tested in trial NCT01059994?
The interventions under investigation include: Sildenafil (DRUG), Placebo sildenafil (DRUG).
Who is sponsoring clinical trial NCT01059994?
This trial is sponsored by The University of Texas Medical Branch, Galveston, which has 203 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01059994's enrollment target sits among peer trials
12 1913th of 2000 higher than 74 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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