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NCT01034527 · ClinicalTrials.gov registry record · NA
Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes
A NA study, sponsored by Children's Hospital Medical Center, Cincinnati.
- Completed
- Registry status
- NA
- Development phase
- 593
- Enrollment target
NCT01034527: Completed NA study, sponsored by Children's Hospital Medical Center, Cincinnati.
NCT01034527 is a NA study that has completed, run by Children's Hospital Medical Center, Cincinnati. The registered enrollment target is 593 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (58% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT01034527, a NA study, has completed, sponsored by Children's Hospital Medical Center, Cincinnati.
- COMPLETED
- Registry status
- NA
- Development phase
- 593 participants
- Enrollment target
Study Summary
Females who participate in cutting and landing sports suffer anterior cruciate ligament (ACL) injuries at a 2 to 10-fold greater rate than males participating in the same high-risk sports. Fifty to 100 percent of ACL injured females will suffer osteoarthritis of the injured knee within one to two decades of the injury. External knee abduction moment (LOAD) predicts ACL injury with high sensitivity and specificity in female athletes. Control of lateral trunk motion (LTM) also predicts ACL injury with similar levels of sensitivity and specificity in female athletes. These predictors may be linked, as lateral positioning of the trunk can create high knee abduction load via both biomechanical and neuromuscular mechanisms. The mechanism of ACL injury in females include high knee LOAD and high LTM, with the majority of body weight shifted over the injured limb and the foot positioned lateral to the body's center of mass. An unanticipated perturbation is also often a contributor to the injury mechanism. LTM may result in increased knee LOAD by increasing the lateral position and magnitude of the GRF vector (ΔGRFv) or by increasing reactive hip adductor torque (HAdT). Our long-term objectives are to determine the mechanisms that cause ACL injury in female athletes and to develop neuromuscular training (NMT) interventions that specifically target these mechanisms. If the objectives of this proposal are achieved, an evidence-based NMT intervention will be developed and made available nationally that will effectively and efficiently reduce ACL injury risk in high-risk female athletes. The major goal of this proposal is to determine if increased LTM increases coronal plane knee load in high-risk groups of female athletes.
Primary Outcome
determine biomechanical risk factors for ACL injury and determine if participation in NMT reduces risk factors compared to sham (speed training)
Interventions
- OTHER Neuromuscular Training
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 593 participants |
| Start Date | 2009-06 |
| Est. Completion | 2013-06 |
| Phase | NA |
What the finished NCT01034527 record still lists
NCT01034527 is an interventional study that assigns participants to a tested intervention. The registered 593 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (58% lower).
The record links to 0 conditions, and to 1 intervention - of which Neuromuscular Training is the first listed.
NCT01034527 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT01034527 about?
NCT01034527 is a clinical study titled "Neuromuscular Intervention Targeted to Mechanisms of ACL Load in Female Athletes". Females who participate in cutting and landing sports suffer anterior cruciate ligament (ACL) injuries at a 2 to 10-fold greater rate than males participating in the same high-risk sports. Fifty to 100 percent of ACL injured females will suffer osteoarthritis of the injured knee within one to two de...
What is the current status of trial NCT01034527?
This trial is currently completed. It is a NA study. The enrollment target is 593 participants. The study started on 2009-06. Estimated completion is 2013-06.
What interventions are being tested in trial NCT01034527?
The interventions under investigation include: Neuromuscular Training (OTHER).
Who is sponsoring clinical trial NCT01034527?
This trial is sponsored by Children's Hospital Medical Center, Cincinnati, which has 571 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT01034527's enrollment target sits among peer trials
593 175th of 2000 higher than 1,826 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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