Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT01020045 · ClinicalTrials.gov registry record
Effect of HIV Infection and Highly Active Antiretroviral Treatment (HAART) on Bone Homeostasis
A clinical trial, sponsored by Emory University.
- Completed
- Registry status
- 120
- Enrollment target
NCT01020045 is a clinical trial that has completed, run by Emory University. The registered enrollment target is 120 participants.
The verdict
NCT01020045 has completed, sponsored by Emory University.
- COMPLETED
- Registry status
- 120 participants
- Enrollment target
Study Summary
Advances in HAART have been a huge success story in the management of HIV infection. However, serious metabolic complications including osteoporosis and bone fractures are increasingly been seen with HAART, and the responsible mechanisms remain poorly elucidated. The skeleton continually regenerates through homeostatic bone remodeling. Osteoclasts the cells responsible for bone resorption form under the influence of the key osteoclastogenic cytokine Receptor- Activator of NF-KB (RANKL). The osteoclastogenic and pro-resorptive activities of RANKL are moderated by its physiological decoy receptor osteoprotegerin (OPG). Increase in the ratio of RANKL to OPG accelerates the rate of osteoclastic bone resorption leading to osteoporosis. The investigators' preliminary studies have now demonstrated that in an animal model of HIV/AIDS, the HIV-1 Transgenic rat, the development of osteoporosis is recapitulated as observed in human patients. Furthermore, the investigators found that B cell expression of OPG is significantly downregulated, concurrent with a significant upregulation in production of RANKL.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 120 participants |
| Start Date | 2010-10 |
| Est. Completion | 2015-10 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT01020045
The ClinicalTrials.gov registry entry for NCT01020045 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 120 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Emory University, which has 1,208 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT01020045 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT01020045 about?
NCT01020045 is a clinical study titled "Effect of HIV Infection and Highly Active Antiretroviral Treatment (HAART) on Bone Homeostasis". Advances in HAART have been a huge success story in the management of HIV infection. However, serious metabolic complications including osteoporosis and bone fractures are increasingly been seen with HAART, and the responsible mechanisms remain poorly elucidated. The skeleton continually regenerate...
What is the current status of trial NCT01020045?
This trial is currently completed. The enrollment target is 120 participants. The study started on 2010-10. Estimated completion is 2015-10.
Who is sponsoring clinical trial NCT01020045?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
Explore more on PlainTrial
Read our methodology - how this data is sourced, computed, and verified.
Related
Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.