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NCT00995670 · ClinicalTrials.gov registry record · NA
Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
A NA study of Hyperglycemia, sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- NA
- Development phase
- 59
- Enrollment target
- 1
- Study location
NCT00995670: Completed NA study of Hyperglycemia, sponsored by US Department of Veterans Affairs.
NCT00995670 is a NA study of Hyperglycemia that has completed, run by US Department of Veterans Affairs. The registered enrollment target is 59 participants, below the 877-participant average among 38 other Hyperglycemia trials with a reported enrollment target (93% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00995670, a NA study of Hyperglycemia, has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- NA
- Development phase
- 59 participants
- Enrollment target
- 1
- Study location
Study Summary
Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and then a re-establishment of flow. The blood vessel lining plays a key role in this injury. This research will examine, in human volunteers, several important modifiers of APC in human blood vessels: high blood sugar, vitamin C, and statin drugs. Thus, the proposed studies will advance the investigators' understanding of mechanisms of this injury in humans and explore important modifiers of APC protection from injury.
Primary Outcome
endothelial (forearm blood flow) responses to acetylcholine stimulation at baseline, and under conditions of high glucose before and after ischemia/reperfusion injury, and same with the addition of an intervention: sevoflurane (Arm 1), vitamin C (Arm 2), and high statin (Arm 3).
Conditions Studied
Interventions
- DRUG Vitamin C
- DRUG Sevoflurane
- DRUG Simvastatin
- DRUG 5% dextrose
Study Locations (1)
Wisconsin
- Zablocki VA Medical Center, Milwaukee - Milwaukee
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 59 participants |
| Start Date | 2010-03 |
| Est. Completion | 2013-09 |
| Phase | NA |
What the finished NCT00995670 record still lists
NCT00995670 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 59 participants, a relatively small participant target, below the 877-participant average among 38 other Hyperglycemia trials with a reported enrollment target (93% lower).
The record links to 1 condition, with Hyperglycemia appearing as the primary indexed condition, and to 4 interventions - of which Vitamin C is the first listed.
NCT00995670 reports a single indexed study location in Wisconsin.
Frequently Asked Questions
What is clinical trial NCT00995670 about?
NCT00995670 is a clinical study titled "Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins". Anesthetic preconditioning (APC, a brief exposure to an anesthetic gas) has become an area of intense research interest because of its ability to protect tissue and organs from injury resulting from a cessation of blood flow and then a re-establishment of flow. The blood vessel lining plays a key ro...
What is the current status of trial NCT00995670?
This trial is currently completed. It is a NA study. The enrollment target is 59 participants. The study started on 2010-03. Estimated completion is 2013-09.
What conditions does trial NCT00995670 study?
This clinical trial studies the following conditions: Hyperglycemia.
What interventions are being tested in trial NCT00995670?
The interventions under investigation include: Vitamin C (DRUG), Sevoflurane (DRUG), Simvastatin (DRUG), 5% dextrose (DRUG).
Who is sponsoring clinical trial NCT00995670?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00995670 being conducted?
This trial has 1 study location across Wisconsin. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00995670's enrollment target sits among peer trials
59 19th of 38 higher than 20 of 38 other Hyperglycemia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Hyperglycemia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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