Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00993421 · ClinicalTrials.gov registry record · Phase 2
A Weight Loss Study in Overweight Men and Women
A Phase 2 study, sponsored by Eli Lilly and Company.
- Terminated
- Registry status
- Phase 2
- Development phase
- 343
- Enrollment target
NCT00993421: Clinical Trial Phase 2 study, sponsored by Eli Lilly and Company.
NCT00993421 is a Phase 2 study that was terminated before completion, run by Eli Lilly and Company. The registered enrollment target is 343 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (158% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00993421, a Phase 2 study, was terminated before completion, sponsored by Eli Lilly and Company.
- TERMINATED
- Registry status
- Phase 2
- Development phase
- 343 participants
- Enrollment target
Study Summary
The purpose of this study is to determine if LY377604 + sibutramine work better than LY377604 or sibutramine alone in the treatment of obesity.
Primary Outcome
Body weight percentage change from baseline is presented as Least Squares Mean (LSMean) with treatment, visit, and their interaction as fixed effects, subject as a random effect, baseline body weight, age, gender were used as covariates.
Interventions
- DRUG Metoprolol
- DRUG Sibutramine
- DRUG LY377604
- DRUG Placebo sibutramine
- DRUG Placebo Metoprolol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 343 participants |
| Start Date | 2009-10 |
| Est. Completion | 2010-06 |
| Phase | Phase 2 |
Why NCT00993421 stopped before completion
NCT00993421 is an interventional study that assigns participants to a tested intervention. The registered 343 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (158% higher).
The record links to 0 conditions, and to 5 interventions - of which Metoprolol is the first listed.
NCT00993421 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00993421 about?
NCT00993421 is a clinical study titled "A Weight Loss Study in Overweight Men and Women". The purpose of this study is to determine if LY377604 + sibutramine work better than LY377604 or sibutramine alone in the treatment of obesity.
What is the current status of trial NCT00993421?
This trial is currently terminated. It is a Phase 2 study. The enrollment target is 343 participants. The study started on 2009-10. Estimated completion is 2010-06.
What interventions are being tested in trial NCT00993421?
The interventions under investigation include: Metoprolol (DRUG), Sibutramine (DRUG), LY377604 (DRUG), Placebo sibutramine (DRUG), Placebo Metoprolol (DRUG).
Who is sponsoring clinical trial NCT00993421?
This trial is sponsored by Eli Lilly and Company, which has 1,341 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00993421's enrollment target sits among peer trials
343 136th of 2000 higher than 1,865 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar enrollment target
- NCT06733363 · 344 participants · Phase 2
A Cruciferous Vegetable Eating Program for the Reduction of Cancer Recurrence and Progression in Patients With Non-muscle Invasive Bladder Cancer
- NCT07179380 · 344 participants · Phase 3
Efficacy and Safety Study of Treprostinil Palmitil Inhalation Powder (TPIP) in Participants With Pulmonary Hypertension Associated With Interstitial Lung Disease (PH-ILD)
- NCT07304024 · 344 participants · Phase 1
A Treatment for a Form of Age-Related Central Auditory Processing Disorder Consisting of Clemastine Fumarate Plus Engineered Sound
- NCT05283850 · 342 participants · Phase 2
Surviving PEA in Roanoke (SPEAR) Study
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia