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NCT00974064 · ClinicalTrials.gov registry record
The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease
A clinical trial, sponsored by Weill Medical College of Cornell University.
- Completed
- Registry status
- 171
- Enrollment target
NCT00974064 is a clinical trial that has completed, run by Weill Medical College of Cornell University. The registered enrollment target is 171 participants.
The verdict
NCT00974064 has completed, sponsored by Weill Medical College of Cornell University.
- COMPLETED
- Registry status
- 171 participants
- Enrollment target
Study Summary
Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD, commonly known as chronic bronchitis and emphysema). Despite this clear link, only 15-20% of smokers develop COPD suggesting that genetic factors affect the lung's susceptibility to the stress of cigarette smoke. The cells lining the airways (epithelium) and cells that help defend the lung (alveolar macrophages) of smokers develop gene expression changes that are different from that of nonsmokers. In the investigators' previous studies they have demonstrated that there are greater than 200 genes that are responsive to cigarette smoke in these cells. But the investigators do not know whether the gene expression is static or changes as a function of time. Genes that show significant changes over time may be relevant to the progression of the disease. Even though quitting smoking reduces the rate at which the lungs decline, many-smokers still go on to develop COPD. This study will provide insights into the natural history of smoking-related gene expression of the lung cells in health and disease.
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 171 participants |
| Start Date | 2009-08 |
| Est. Completion | 2013-06 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00974064
The ClinicalTrials.gov registry entry for NCT00974064 describes a study currently listed as completed, categorized as an unspecified phase. The registered enrollment target is 171 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Weill Medical College of Cornell University, which has 701 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 0 interventions.
NCT00974064 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00974064 about?
NCT00974064 is a clinical study titled "The Natural History of Gene Expression in the Lung Cells of Non-Smokers, Smokers and Ex-Smokers in Health and Disease". Cigarette smoking is the major risk factor for chronic obstructive pulmonary disease (COPD, commonly known as chronic bronchitis and emphysema). Despite this clear link, only 15-20% of smokers develop COPD suggesting that genetic factors affect the lung's susceptibility to the stress of cigarette sm...
What is the current status of trial NCT00974064?
This trial is currently completed. The enrollment target is 171 participants. The study started on 2009-08. Estimated completion is 2013-06.
Who is sponsoring clinical trial NCT00974064?
This trial is sponsored by Weill Medical College of Cornell University, which has 701 total clinical trials registered on ClinicalTrials.gov.
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