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NCT00950118 · ClinicalTrials.gov registry record
Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science
A clinical trial of Congenital Diaphragmatic Hernia, sponsored by Columbia University.
- Recruiting
- Registry status
- 3,000
- Enrollment target
- 14
- Study locations
NCT00950118: Recruiting study of Congenital Diaphragmatic Hernia, sponsored by Columbia University.
NCT00950118 is a study of Congenital Diaphragmatic Hernia that is actively recruiting participants, run by Columbia University. The registered enrollment target is 3,000 participants, above the 60-participant average among 22 other Congenital Diaphragmatic Hernia trials with a reported enrollment target (4900% higher). The trial reports 14 study locations across 12 states. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00950118, a study of Congenital Diaphragmatic Hernia, is actively recruiting participants, sponsored by Columbia University.
- RECRUITING
- Registry status
- 3,000 participants
- Enrollment target
- 14
- Study locations
Study Summary
The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of congenital diaphragmatic hernia. There are many different possible modes of inheritance for congenital anomalies, including autosomal dominant, autosomal recessive, and multifactorial. Multi-factorial inheritance is responsible for many common medical disorders, including hypertension, myocardial infarction, diabetes and cancer. This type of inheritance pattern appears to involve environmental factors as well as a combination of genetic variations that together can predispose to or produce congenital anomalies, such as congenital diaphragmatic hernia. Our study is designed to establish a small, well-defined genetic resource consisting of 1) Nuclear families suitable for linkage analysis by parametric,non-parametric (e.g. sib pairs, TDT) and association techniques, 2) Individuals with congenital diaphragmatic hernia who can be directly screened for allelic variation in candidate genes, and 3) Individuals who can serve as controls (are unaffected by congenital diaphragmatic hernia). Neonates and their families will be collected from homogenous and heterogeneous populations. By characterizing diverse populations, it should be possible to increase the likelihood of demonstration of genetic variation in selected candidate genes that can then be used in association and linkage studies in individual subjects with congenital diaphragmatic hernia.
Primary Outcome
DNA samples from patients will be analyzed for underlying genetic causes.
Conditions Studied
Study Locations (14)
New York
- Northwell Health - Manhasset
- New York University, Hassenfeld Children's Hospital at NYU Langone Health - New York
- Morgan Stanley Children's Hospital of New York- Presbyterian (Columbia University Medical Center) - New York
Illinois
- Rush Hospital - Chicago
Michigan
- University of Michigan/ CS Mott Children's Hospital - Ann Arbor
Missouri
- Washington University Medical Center/ St. Louis Children's Hospital - St Louis
Nebraska
- Children's Hospital of Omaha/ University of Nebraska - Omaha
Ohio
- Cincinnati Children's Hospital and Medical Center/ University of Cincinnati - Cincinnati
Oregon
- Oregon Health & Science University, Doernbecher Children's Hospital - Portland
Pennsylvania
- Children's Hospital of Pittsburgh/ University of Pittsburgh - Pittsburgh
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3,000 participants |
| Start Date | 2005-06 |
| Est. Completion | 2026-09 |
What NCT00950118 shows while recruiting
NCT00950118 is an observational study that tracks outcomes without assigning an intervention. Its 3,000 participants enrollment target places it among the larger protocols in the corpus, above the 60-participant average among 22 other Congenital Diaphragmatic Hernia trials with a reported enrollment target (4900% higher).
The record links to 1 condition, with Congenital Diaphragmatic Hernia appearing as the primary indexed condition, and to 0 interventions.
NCT00950118 lists 14 locations in 12 states (New York, Illinois, Michigan).
Frequently Asked Questions
What is clinical trial NCT00950118 about?
NCT00950118 is a clinical study titled "Diaphragmatic Hernia Research & Exploration, Advancing Molecular Science". The goal of this study is to identify genes that convey susceptibility to congenital diaphragmatic hernia in humans. The identification of such genes, and examination of their structure and function, will enable a delineation of molecular pathogenesis and, ultimately, prevention or treatment of cong...
What is the current status of trial NCT00950118?
This trial is currently recruiting. The enrollment target is 3,000 participants. The study started on 2005-06. Estimated completion is 2026-09.
What conditions does trial NCT00950118 study?
This clinical trial studies the following conditions: Congenital Diaphragmatic Hernia.
Who is sponsoring clinical trial NCT00950118?
This trial is sponsored by Columbia University, which has 958 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00950118 being conducted?
This trial has 14 study locations across Illinois, Michigan, Missouri, Nebraska, New York. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Congenital Diaphragmatic Hernia
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00950118's enrollment target sits among peer trials
3,000 1st of 22 higher than 22 of 22 other Congenital Diaphragmatic Hernia trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Congenital Diaphragmatic Hernia trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
-
Pilot Trial of Fetoscopic Endoluminal Tracheal Occlusion (FETO) in Severe Left Congenital Diaphragmatic Hernia (CDH)
RECRUITING · NA
-
Fetal Endoscopic Tracheal Occlusion (FETO) Trial for Congenital Diaphragmatic Hernia (CDH)
RECRUITING · NA
-
De-implementing Inhaled Nitric Oxide for Congenital Diaphragmatic Hernia
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A Trial of Phosphodiesterase-5 Inhibitor in Neonatal Congenital Diaphragmatic Hernia (TOP-CDH)
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Safety and Efficacy of FETO in CDH: A Phase III Trial
RECRUITING · NA
-
Trial of FETO for Severe Congenital Diaphragmatic Hernia
RECRUITING · NA
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