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NCT00945464 · ClinicalTrials.gov registry record
Scripps Polster Breast Care Center Investigational GeneBank
A clinical trial of Breast Cancer, sponsored by Scripps Translational Science Institute.
- Completed
- Registry status
- 1,136
- Enrollment target
- 1
- Study location
NCT00945464: Completed study of Breast Cancer, sponsored by Scripps Translational Science Institute.
NCT00945464 is a study of Breast Cancer that has completed, run by Scripps Translational Science Institute. The registered enrollment target is 1,136 participants, below the 2,802-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (59% lower). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00945464, a study of Breast Cancer, has completed, sponsored by Scripps Translational Science Institute.
- COMPLETED
- Registry status
- 1,136 participants
- Enrollment target
- 1
- Study location
Study Summary
Breast cancer is a disease of complex origin with a strong genetic component. The incidence of breast cancer is very high in monozygotic twins of patients, and it is thought that a high proportion and perhaps the majority of breast cancers arise in a small number of genetically susceptible women. Recent studies in human genetics have discovered several intervals in the human genome containing inherited variants that are statistically associated with the propensity to develop breast cancer. The investigators plan to use this knowledge to design a genetic screening test to guide recommendations for breast cancer screening with mammography. If the small group of genetically susceptible women can be identified, more effective breast cancer screening strategies can be implemented. In contrast, a very large proportion of women who undergo yearly mammography are at exceptionally low risk from a genetic perspective. Using genomic guidance could eventually reconfigure the most efficacious strategy to screen women for early detection of breast cancer. By developing a genetic screening panel based on genetic markers for breast cancer, the investigators will be able to more accurately determine a woman's individual risk for developing breast cancer.
Primary Outcome
Genotype a panel of single nucleotide polymorphisms (SNPs) previously shown to be highly associated with increased risk to breast cancer in a cohort of women with either at least 5 years of historical breast imaging data available or 30-45 year old breast cancer patients with at least one year imaging data
Conditions Studied
Interventions
- OTHER Blood/saliva samples, historic breast imaging
Study Locations (1)
California
- Scripps Polster Breast Care Center - La Jolla
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 1,136 participants |
| Start Date | 2008-07 |
| Est. Completion | 2015-06 |
What the finished NCT00945464 record still lists
NCT00945464 is an observational study that tracks outcomes without assigning an intervention. Its 1,136 participants enrollment target places it among the larger protocols in the corpus, below the 2,802-participant average among 1,224 other Breast Cancer trials with a reported enrollment target (59% lower).
The record links to 1 condition, with Breast Cancer appearing as the primary indexed condition, and to 1 intervention - of which Blood/saliva samples, historic breast imaging is the first listed.
NCT00945464 reports a single indexed study location in California.
Frequently Asked Questions
What is clinical trial NCT00945464 about?
NCT00945464 is a clinical study titled "Scripps Polster Breast Care Center Investigational GeneBank". Breast cancer is a disease of complex origin with a strong genetic component. The incidence of breast cancer is very high in monozygotic twins of patients, and it is thought that a high proportion and perhaps the majority of breast cancers arise in a small number of genetically susceptible women. Re...
What is the current status of trial NCT00945464?
This trial is currently completed. The enrollment target is 1,136 participants. The study started on 2008-07. Estimated completion is 2015-06.
What conditions does trial NCT00945464 study?
This clinical trial studies the following conditions: Breast Cancer.
What interventions are being tested in trial NCT00945464?
The interventions under investigation include: Blood/saliva samples, historic breast imaging (OTHER).
Who is sponsoring clinical trial NCT00945464?
This trial is sponsored by Scripps Translational Science Institute, which has 41 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00945464 being conducted?
This trial has 1 study location across California. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
Similar trials for Breast Cancer
Matched on the same primary condition, ranked to surface studies in the same phase first, then by recruiting status, no relevance scoring or editorial curation.
Where NCT00945464's enrollment target sits among peer trials
1,136 109th of 1224 higher than 1,116 of 1,224 other Breast Cancer trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Breast Cancer trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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