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NCT00943774 · ClinicalTrials.gov registry record
High Resolution Phenotyping in Healthy Humans
A clinical trial, sponsored by Mayo Clinic.
- Completed
- Registry status
- 300
- Enrollment target
NCT00943774: Completed study, sponsored by Mayo Clinic.
NCT00943774 is a clinical trial that has completed, run by Mayo Clinic. The registered enrollment target is 300 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00943774 has completed, sponsored by Mayo Clinic.
- COMPLETED
- Registry status
- 300 participants
- Enrollment target
Study Summary
Baroreflex sensitivity is integral to blood pressure regulation, and varies among healthy, normotensive individuals. A reduced compensatory ability of baroreflex buffering in patients with carotid denervation results in blood pressure variability and an elevated blood pressure response to mental stress. Furthermore, 24-hour ambulatory blood pressure variability may also be a significant and independent risk determinant of cardiovascular disease. It remains unknown whether the degree of baroreflex sensitivity and ambulatory blood pressure variability are predictive of the pressor response to sympathoexcitatory stress in healthy humans. In this study the investigators propose a comprehensive evaluation of the relationships among the pressor and forearm vasodilator response to sympathoexcitation, ambulatory blood pressure variability, and baroreflex sensitivity in healthy normotensive subjects. Ultimately this study will provide preliminary data and protocol development for large-scale high resolution phenotyping in population-based trials aimed at determining the functional relevance of candidate gene variation in intermediate physiological traits pertinent to the pathogenesis of hypertension and cardiovascular disease.
Interventions
- OTHER Physiological maneuvers
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 300 participants |
| Start Date | 2006-04 |
| Est. Completion | 2013-02 |
What the finished NCT00943774 record still lists
NCT00943774 is an observational study that tracks outcomes without assigning an intervention. The registered 300 participants enrollment target is mid-sized for trials with a published cap.
The record links to 0 conditions, and to 1 intervention - of which Physiological maneuvers is the first listed.
NCT00943774 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00943774 about?
NCT00943774 is a clinical study titled "High Resolution Phenotyping in Healthy Humans". Baroreflex sensitivity is integral to blood pressure regulation, and varies among healthy, normotensive individuals. A reduced compensatory ability of baroreflex buffering in patients with carotid denervation results in blood pressure variability and an elevated blood pressure response to mental str...
What is the current status of trial NCT00943774?
This trial is currently completed. The enrollment target is 300 participants. The study started on 2006-04. Estimated completion is 2013-02.
What interventions are being tested in trial NCT00943774?
The interventions under investigation include: Physiological maneuvers (OTHER).
Who is sponsoring clinical trial NCT00943774?
This trial is sponsored by Mayo Clinic, which has 2,844 total clinical trials registered on ClinicalTrials.gov.
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