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COMPLETED Phase 2

Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Patients

NCT00931918 · View on ClinicalTrials.gov ↗

Study Summary

This is a randomized, open-label, multi-center, phase 2 study of RCHOP with or without VELCADE in adult patients with previously untreated non-(Germinal B-Cell-like) GCB Diffuse Large B-cell Lymphoma (DLBCL). The study will determine whether the addition of VELCADE to RCHOP improves progression-free survival (PFS) in patients with non-GCB DLBCL.

Interventions

  • DRUG Cyclophosphamide
  • DRUG Doxorubicin
  • DRUG Rituximab
  • DRUG Vincristine
  • DRUG Bortezomib

Study Locations (20)

California

  • Tower Cancer Research Foundation — Beverly Hills
  • Fountain Valley Regional Hospital — Fountain Valley
  • St. Jude Heritage Healthcare — Fullerton
  • Moores Cancer Center- UCSD — La Jolla
  • Antelope Valley Cancer Center — Lancaster
  • Loma Linda University Cancer Center — Loma Linda
  • University of Southern California — Los Angeles
  • Jonsson Comprehensive Cancer Center — Los Angeles
  • TORI- Central Pharmacy — Los Angeles
  • TORI- Central Regulatory — Los Angeles
  • Oncology Care Medical Associates — Montebello
  • Bay Area Cancer Research Group — Pleasant Hill
  • Wilshire Oncology Medical Group — Rancho Cucamonga
  • Sharp Healthcare — San Diego
  • Central Coast Medical Oncology Corporation — Santa Maria

Florida

  • Florida Cancer Specialists — Fort Myers
  • Florida Cancer Specialists & Research Institute — Gainsville
  • Alves/ Domenech Oncology-Hematology Clinic — Hollywood
  • Florida Cancer Institute ATI — New Port Richey

Colorado

  • Rocky Mountain Cancer Center — Denver

Trial Details

FieldValue
Enrollment Target 206 participants
Start Date 2009-10
Est. Completion 2015-08
Phase Phase 2

Sponsor

Millennium Pharmaceuticals

21 total trials

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Full Details on ClinicalTrials.gov ↗

What the Registry Record Tells You About NCT00931918

The ClinicalTrials.gov registry entry for NCT00931918 describes a study currently listed as completed. It is categorized as Phase 2, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 206 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Millennium Pharmaceuticals, which has 21 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.

The record links to 1 condition, with Non-Germinal B-Cell-like (GCB) Diffuse Large B-cell Lymphoma (DLBCL) appearing as the primary indexed condition, and to 5 interventions — of which Cyclophosphamide is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.

Geographic footprint matters for practical reasons: NCT00931918 reports 20 study locations spanning 3 distinct geographic areas — top geographies include California, Florida, Colorado. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.

Frequently Asked Questions

What is clinical trial NCT00931918 about?

NCT00931918 is a clinical study titled "Study to Assess the Effectiveness of RCHOP With or Without VELCADE in Previously Untreated Non-Germinal Center B-Cell-like Diffuse Large B-Cell Lymphoma Patients". This is a randomized, open-label, multi-center, phase 2 study of RCHOP with or without VELCADE in adult patients with previously untreated non-(Germinal B-Cell-like) GCB Diffuse Large B-cell Lymphoma (DLBCL). The study will determine whether the addition of VELCADE to RCHOP improves progression-free...

What is the current status of trial NCT00931918?

This trial is currently completed. It is a Phase 2 study. The enrollment target is 206 participants. The study started on 2009-10. Estimated completion is 2015-08.

What conditions does trial NCT00931918 study?

This clinical trial studies the following conditions: Non-Germinal B-Cell-like (GCB) Diffuse Large B-cell Lymphoma (DLBCL). These conditions were identified from the trial registry and reflect the primary focus areas of the research.

What interventions are being tested in trial NCT00931918?

The interventions under investigation include: Cyclophosphamide (DRUG), Doxorubicin (DRUG), Rituximab (DRUG), Vincristine (DRUG), Bortezomib (DRUG). Each intervention is being evaluated for safety and efficacy as part of this clinical study.

Who is sponsoring clinical trial NCT00931918?

This trial is sponsored by Millennium Pharmaceuticals, which has 21 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.

Where is trial NCT00931918 being conducted?

This trial has 20 study locations across California, Colorado, Florida. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

Related

Data sourced from official U.S. government datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial