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NCT00899600 · ClinicalTrials.gov registry record · NA
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
A NA study, sponsored by Dartmouth-Hitchcock Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 102
- Enrollment target
NCT00899600: Completed NA study, sponsored by Dartmouth-Hitchcock Medical Center.
NCT00899600 is a NA study that has completed, run by Dartmouth-Hitchcock Medical Center. The registered enrollment target is 102 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00899600, a NA study, has completed, sponsored by Dartmouth-Hitchcock Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 102 participants
- Enrollment target
Study Summary
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements. The pathophysiology of central sensitization is thought to involve excitatory amino acid receptors such as N-methyl-d-aspartate (NMDA) (1, 2). Ketamine is a N-methyl-d-aspartate (NMDA) receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption in a variety of surgical interventions (3). Spine surgery provides a unique opportunity to evaluate the preemptive and preventative impact of ketamine on the primary end points of postoperative 24 and 48 hour opioid consumption in patients with chronic pain. The goal of this double blinded, prospective, randomized placebo controlled trial is to quantify the preemptive and preventative analgesic effects of ketamine infusions in this patient population. Such insight may lead to better pain control, improved satisfaction, and ultimately a reduction in side-effects related to postoperative opioid use.
Primary Outcome
Total morphine(mg)consumed at 48 hours.
Interventions
- DRUG Ketamine
- OTHER Normal saline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2007-02 |
| Est. Completion | 2009-04 |
| Phase | NA |
What the finished NCT00899600 record still lists
NCT00899600 is an interventional study that assigns participants to a tested intervention. The registered 102 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (93% lower).
The record links to 0 conditions, and to 2 interventions - of which Ketamine is the first listed.
NCT00899600 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00899600 about?
NCT00899600 is a clinical study titled "Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain". Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements. The pathophysiology of central sensitization is thought to involve excitatory amino acid receptors such as N-methyl-d-aspartate ...
What is the current status of trial NCT00899600?
This trial is currently completed. It is a NA study. The enrollment target is 102 participants. The study started on 2007-02. Estimated completion is 2009-04.
What interventions are being tested in trial NCT00899600?
The interventions under investigation include: Ketamine (DRUG), Normal saline (OTHER).
Who is sponsoring clinical trial NCT00899600?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 427 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00899600's enrollment target sits among peer trials
102 837th of 2000 higher than 1,161 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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