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NCT00899600 · ClinicalTrials.gov registry record · NA
Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain
A NA study, sponsored by Dartmouth-Hitchcock Medical Center.
- Completed
- Registry status
- NA
- Development phase
- 102
- Enrollment target
NCT00899600 is a NA study that has completed, run by Dartmouth-Hitchcock Medical Center. The registered enrollment target is 102 participants.
The verdict
NCT00899600, a NA study, has completed, sponsored by Dartmouth-Hitchcock Medical Center.
- COMPLETED
- Registry status
- NA
- Development phase
- 102 participants
- Enrollment target
Study Summary
Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements. The pathophysiology of central sensitization is thought to involve excitatory amino acid receptors such as N-methyl-d-aspartate (NMDA) (1, 2). Ketamine is a N-methyl-d-aspartate (NMDA) receptor antagonist that has been shown to be useful in the reduction of acute postoperative pain and analgesic consumption in a variety of surgical interventions (3). Spine surgery provides a unique opportunity to evaluate the preemptive and preventative impact of ketamine on the primary end points of postoperative 24 and 48 hour opioid consumption in patients with chronic pain. The goal of this double blinded, prospective, randomized placebo controlled trial is to quantify the preemptive and preventative analgesic effects of ketamine infusions in this patient population. Such insight may lead to better pain control, improved satisfaction, and ultimately a reduction in side-effects related to postoperative opioid use.
Interventions
- DRUG Ketamine
- OTHER Normal saline
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 102 participants |
| Start Date | 2007-02 |
| Est. Completion | 2009-04 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00899600
The ClinicalTrials.gov registry entry for NCT00899600 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 102 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Dartmouth-Hitchcock Medical Center, which has 427 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Ketamine is the first listed.
NCT00899600 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00899600 about?
NCT00899600 is a clinical study titled "Intra-operative Ketamine Infusions in Opioid-dependent Patients With Chronic Lower Back Pain". Noxious stimuli occurring intraoperatively and postoperatively generate central sensitization, decreasing pain thresholds and ultimately increasing analgesic requirements. The pathophysiology of central sensitization is thought to involve excitatory amino acid receptors such as N-methyl-d-aspartate ...
What is the current status of trial NCT00899600?
This trial is currently completed. It is a NA study. The enrollment target is 102 participants. The study started on 2007-02. Estimated completion is 2009-04.
What interventions are being tested in trial NCT00899600?
The interventions under investigation include: Ketamine (DRUG), Normal saline (OTHER).
Who is sponsoring clinical trial NCT00899600?
This trial is sponsored by Dartmouth-Hitchcock Medical Center, which has 427 total clinical trials registered on ClinicalTrials.gov.
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