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NCT00855244 · ClinicalTrials.gov registry record · NA
Metabolic Syndrome in Bone Marrow Transplant Survivors
A NA study, sponsored by Nationwide Children's Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 5
- Enrollment target
NCT00855244 is a NA study that was terminated before completion, run by Nationwide Children's Hospital. The registered enrollment target is 5 participants.
The verdict
NCT00855244, a NA study, was terminated before completion, sponsored by Nationwide Children's Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 5 participants
- Enrollment target
Study Summary
Life for long-term bone marrow transplant patients is complicated by endocrine late effects including growth hormone (GH) deficiency, thyroid hormone deficiency and sex steroid deficiency. Recently, studies have also identified problems with metabolic syndrome in adult bone marrow transplant (BMT) survivors. Metabolic syndrome has been identified as a constellation of insulin resistance, truncal obesity and high lipid levels (dyslipidemia) and is associated with an increased risk of type 2 diabetes and cardiovascular disease. Thus the early identification of metabolic syndrome is important. To date, studies have not identified how young an age metabolic syndrome begins in BMT survivors. The investigators' study will consist of two aims: 1. Evaluation of children who have survived BMT for growth hormone deficiency, abnormal lipid metabolism, hypothyroidism and gonadal dysgenesis. The investigators will utilize growth hormone stimulation testing, sex steroid levels, an oral glucose tolerance test (OGTT) and fasting lipid profile to evaluate for concomitant endocrinopathy, prediabetes and impaired glucose tolerance in a cohort of BMT survivors. 2. Cross-sectional study of peripheral and hepatic insulin sensitivity in children surviving BMT using a hyperinsulinemic euglycemic clamp and the stable isotope 6,6 \[2H2\] glucose. These aims will provide pilot data to power the first definitive study of insulin resistance in childhood BMT survivors.
Interventions
- OTHER Diagnostic exams
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 5 participants |
| Start Date | 2009-03 |
| Est. Completion | 2010-05 |
| Phase | NA |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00855244
The ClinicalTrials.gov registry entry for NCT00855244 describes a study currently listed as terminated, categorized as NA. The registered enrollment target is 5 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Nationwide Children's Hospital, which has 188 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Diagnostic exams is the first listed.
NCT00855244 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00855244 about?
NCT00855244 is a clinical study titled "Metabolic Syndrome in Bone Marrow Transplant Survivors". Life for long-term bone marrow transplant patients is complicated by endocrine late effects including growth hormone (GH) deficiency, thyroid hormone deficiency and sex steroid deficiency. Recently, studies have also identified problems with metabolic syndrome in adult bone marrow transplant (BMT) s...
What is the current status of trial NCT00855244?
This trial is currently terminated. It is a NA study. The enrollment target is 5 participants. The study started on 2009-03. Estimated completion is 2010-05.
What interventions are being tested in trial NCT00855244?
The interventions under investigation include: Diagnostic exams (OTHER).
Who is sponsoring clinical trial NCT00855244?
This trial is sponsored by Nationwide Children's Hospital, which has 188 total clinical trials registered on ClinicalTrials.gov.
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