Molecular-Genetic Correlates of Fatigue in Cancer Patients Receiving Localized External Beam Radiation Therapy

Study Summary

Background: * Researchers have studied the causes of fatigue during treatments for various diseases, but these results have not been conclusive. * More information on the physical changes that affect the body during treatment may help identify biological or chemical factors that contribute to patient fatigue, which may allow physicians to identify individuals who may be more at risk of feeling fatigue before, during, and after treatment for diseases such as cancer. Objectives: * To identify factors contributing to fatigue in men who are undergoing radiation treatment for prostate cancer. Eligibility: * Men 18 years of age and older who are scheduled to receive localized radiation treatment for prostate cancer. Design: * Six outpatient visits to the NIH Clinical Center, approximately on the same day and same time of day: * First visit before beginning radiation treatment. * Once a week for the first 2 weeks of the treatment, once at the midpoint of treatment, once at the end of treatment. * Final visit 4 weeks after completion of radiation treatment. * Initial visit will involve a physical examination and questions about medical history. * Evaluations during the treatment period: * Blood draws to identify cells and chemicals associated with inflammation and fatigue. * Questions about physical activity, fatigue, depression, and quality of life.