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NCT00842621 · ClinicalTrials.gov registry record
Long Term Effects of Erythrocyte Lysis
A clinical trial of Sickle Cell Disease and Hemolytic Anemia, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- 390
- Enrollment target
- 1
- Study location
NCT00842621: Completed study of Sickle Cell Disease and Hemolytic Anemia, sponsored by St. Jude Children's Research Hospital.
NCT00842621 is a study of Sickle Cell Disease and Hemolytic Anemia that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 390 participants, above the 291-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (34% higher). The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00842621, a study of Sickle Cell Disease and Hemolytic Anemia, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- 390 participants
- Enrollment target
- 1
- Study location
Study Summary
In this prospective observational trial, participants with chronic hemolysis will be assessed with echocardiogram for elevated tricuspid jet velocity and other evidence of pulmonary hypertension. Participants will have laboratory studies evaluating: severity of hemolysis, splenic function, inflammation, endothelial dysfunction, and hypercoagulability. There will be 3 main categories of participants enrolled in this study: (1) pediatric participants with severe sickle cell disease (SCD) (HbSS, HbS/β° thalassemia ) who are not receiving treatment (e.g., hydroxyurea or chronic transfusions); (2) pediatric participants with other forms of SCD or severe SCD (HbSS, HbS/β° thalassemia) patients being treated with hydroxyurea or chronic transfusions; and (3) pediatric and adult participants with other non-sickling hematological disorders.
Conditions Studied
Interventions
- PROCEDURE Clinical Evaluations
- OTHER Laboratory Studies
Study Locations (1)
Tennessee
- St. Jude Children's Research Hospital - Memphis
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 390 participants |
| Start Date | 2009-03 |
| Est. Completion | 2016-06 |
What the finished NCT00842621 record still lists
NCT00842621 is an observational study that tracks outcomes without assigning an intervention. The registered 390 participants enrollment target is mid-sized for trials with a published cap, above the 291-participant average among 213 other Sickle Cell Disease trials with a reported enrollment target (34% higher).
The record links to 2 conditions, with Sickle Cell Disease appearing as the primary indexed condition, and to 2 interventions - of which Clinical Evaluations is the first listed.
NCT00842621 reports a single indexed study location in Tennessee.
Frequently Asked Questions
What is clinical trial NCT00842621 about?
NCT00842621 is a clinical study titled "Long Term Effects of Erythrocyte Lysis". In this prospective observational trial, participants with chronic hemolysis will be assessed with echocardiogram for elevated tricuspid jet velocity and other evidence of pulmonary hypertension. Participants will have laboratory studies evaluating: severity of hemolysis, splenic function, inflammat...
What is the current status of trial NCT00842621?
This trial is currently completed. The enrollment target is 390 participants. The study started on 2009-03. Estimated completion is 2016-06.
What conditions does trial NCT00842621 study?
This clinical trial studies the following conditions: Sickle Cell Disease, Hemolytic Anemia.
What interventions are being tested in trial NCT00842621?
The interventions under investigation include: Clinical Evaluations (PROCEDURE), Laboratory Studies (OTHER).
Who is sponsoring clinical trial NCT00842621?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00842621 being conducted?
This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
Learn More About Clinical Trials
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Where NCT00842621's enrollment target sits among peer trials
390 13th of 213 higher than 201 of 213 other Sickle Cell Disease trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Sickle Cell Disease trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
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