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NCT00802230 · ClinicalTrials.gov registry record · Phase 4
Pharmacodynamic Study of Carvedilol Versus Metoprolol in Heart Failure
A Phase 4 study, sponsored by University of Utah.
- Completed
- Registry status
- Phase 4
- Development phase
- 25
- Enrollment target
NCT00802230: Completed Phase 4 study, sponsored by University of Utah.
NCT00802230 is a Phase 4 study that has completed, run by University of Utah. The registered enrollment target is 25 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00802230, a Phase 4 study, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 25 participants
- Enrollment target
Study Summary
Metoprolol succinate is a beta1-selective beta-blocker, becoming non-selective at higher doses, while carvedilol is non-selective. We examined whether metoprolol remained beta1-selective compared to carvedilol during dose up-titration in Class C heart failure (HF) Beta-blocker naïve patients. METHODS: Twenty-five NYHA FC II-III HF patients were randomized to carvedilol or metoprolol. Patients were studied at baseline and after 2 weeks of up-titration (metoprolol at 25, 50, 100, and 200 mg daily; carvedilol IR at 3.125, 6.25, 12.5, 25 mg and 50mg twice daily). Beta2- blockade was determined by an infusion of terbutaline at 6 mg/kg over 1 hour. Glucose and potassium levels were serially measured at baseline, every 15 minutes for the 1st hour and 30 minutes for 2nd hour post-infusion. The median area under the curve (AUC) for glucose and potassium changes were calculated.
Interventions
- DRUG Terbutaline Infusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 25 participants |
| Start Date | 2002-09 |
| Est. Completion | 2004-12 |
| Phase | Phase 4 |
What the finished NCT00802230 record still lists
NCT00802230 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 25 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 1 intervention - of which Terbutaline Infusion is the first listed.
NCT00802230 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00802230 about?
NCT00802230 is a clinical study titled "Pharmacodynamic Study of Carvedilol Versus Metoprolol in Heart Failure". Metoprolol succinate is a beta1-selective beta-blocker, becoming non-selective at higher doses, while carvedilol is non-selective. We examined whether metoprolol remained beta1-selective compared to carvedilol during dose up-titration in Class C heart failure (HF) Beta-blocker naïve patients. METHO...
What is the current status of trial NCT00802230?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 25 participants. The study started on 2002-09. Estimated completion is 2004-12.
What interventions are being tested in trial NCT00802230?
The interventions under investigation include: Terbutaline Infusion (DRUG).
Who is sponsoring clinical trial NCT00802230?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00802230's enrollment target sits among peer trials
25 1669th of 2000 higher than 302 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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