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NCT00787124 · ClinicalTrials.gov registry record
Transfusions and Nitric Oxide Level in Preterm Infants
A clinical trial, sponsored by Duke University.
- Completed
- Registry status
- 8
- Enrollment target
NCT00787124: Completed study, sponsored by Duke University.
NCT00787124 is a clinical trial that has completed, run by Duke University. The registered enrollment target is 8 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00787124 has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- 8 participants
- Enrollment target
Study Summary
The purpose of this study is to better understand S-nitrosohemeglobin (SNO-Hb) in transfused blood of extremely preterm infants. The long term goal of the project is to identify variation in the SNO-Hb between packed red blood cell units, and between and among individual preterm infants pre and post-transfusion. Duke investigators are developing methods to replenish SNO-Hb, which, if successful, would improve RBC deformation in addition to providing a vasodilatory stimulation to hypoxic tissue, and lead to a randomized clinical trial testing treated vs. untreated RBC transfusions in extremely premature infants. AIM 1. Measure the Total Hemoglobin (Hb)-bound nitric oxide (NO), Hb \[Fe\] NO, SNO-Hb (a calculated value = (total Hb-NO - Hb \[Fe\] NO) in blood to be transfused in extremely preterm babies, and in samples pre and post- transfusion from the babies. Hypothesis 1: Measures of NO and SNO-Hb will be low in blood used for transfusion in preterm infants and will be decreased in the post-transfusion samples from the infants compared with the pre-transfusion samples. AIM 2. Collect clinical data about study participants, including oxygen saturation and measures of perfusion pre and post-transfusion. Hypothesis 2: Measures of perfusion will be reduced by 20% post-transfusion in extremely preterm infants.
Primary Outcome
levels were never run by the laboratory
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 8 participants |
| Start Date | 2008-09 |
| Est. Completion | 2009-09 |
What the finished NCT00787124 record still lists
NCT00787124 is an observational study that tracks outcomes without assigning an intervention. The registry caps enrollment at 8 participants, a relatively small participant target.
The record links to 0 conditions, and to 0 interventions.
NCT00787124 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00787124 about?
NCT00787124 is a clinical study titled "Transfusions and Nitric Oxide Level in Preterm Infants". The purpose of this study is to better understand S-nitrosohemeglobin (SNO-Hb) in transfused blood of extremely preterm infants. The long term goal of the project is to identify variation in the SNO-Hb between packed red blood cell units, and between and among individual preterm infants pre and post...
What is the current status of trial NCT00787124?
This trial is currently completed. The enrollment target is 8 participants. The study started on 2008-09. Estimated completion is 2009-09.
Who is sponsoring clinical trial NCT00787124?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
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