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NCT00770328 · ClinicalTrials.gov registry record · Phase 4

The Effects of Pentoxifylline on PAI-1 in an Obese Population

A Phase 4 study of Obesity, sponsored by Vanderbilt University.

Completed
Registry status
Phase 4
Development phase
37
Enrollment target
1
Study location

NCT00770328 is a Phase 4 study of Obesity that has completed, run by Vanderbilt University. The registered enrollment target is 37 participants, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower). The trial reports 1 study location across 1 state.

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The verdict

NCT00770328, a Phase 4 study of Obesity, has completed, sponsored by Vanderbilt University.

COMPLETED
Registry status
Phase 4
Development phase
37 participants
Enrollment target
1
Study location

Study Summary

PAI-1 is elevated in obese individuals. TNF-alpha, an inflammatory mediator is believed to play a role in obesity mediated elevations in PAI-1 levels. TNF-alpha blockade with antibodies and the drug pentoxifylline have been shown to lower PAI-1 levels in animal models. This study tests the hypothesis that pentoxifylline will lower PAI-1 levels in human subjects.

Conditions Studied

Obesity

Interventions

  • DRUG Placebo
  • DRUG Pentoxifylline

Study Locations (1)

Tennessee

  • Vanderbilt University Medical Center - Nashville

Trial Details

FieldValue
Enrollment Target 37 participants
Start Date 2003-05
Est. Completion 2009-06
Phase Phase 4

Sponsor

Vanderbilt University

430 total trials

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What the Registry Record Tells You About NCT00770328

The ClinicalTrials.gov registry entry for NCT00770328 describes a study currently listed as completed, categorized as Phase 4. The registered enrollment target is 37 participants, a figure that helps gauge the scale of data the investigators plan to collect, below the 819-participant average among 1,053 other Obesity trials with a reported enrollment target (95% lower). The listed sponsor is Vanderbilt University, which has 430 total studies on file at ClinicalTrials.gov.

The record links to 1 condition, with Obesity appearing as the primary indexed condition, and to 2 interventions - of which Placebo is the first listed.

NCT00770328 reports 1 study location spanning 1 distinct geographic area - top geographies include Tennessee.

Frequently Asked Questions

What is clinical trial NCT00770328 about?

NCT00770328 is a clinical study titled "The Effects of Pentoxifylline on PAI-1 in an Obese Population". PAI-1 is elevated in obese individuals. TNF-alpha, an inflammatory mediator is believed to play a role in obesity mediated elevations in PAI-1 levels. TNF-alpha blockade with antibodies and the drug pentoxifylline have been shown to lower PAI-1 levels in animal models. This study tests the hypothesi...

What is the current status of trial NCT00770328?

This trial is currently completed. It is a Phase 4 study. The enrollment target is 37 participants. The study started on 2003-05. Estimated completion is 2009-06.

What conditions does trial NCT00770328 study?

This clinical trial studies the following conditions: Obesity.

What interventions are being tested in trial NCT00770328?

The interventions under investigation include: Placebo (DRUG), Pentoxifylline (DRUG).

Who is sponsoring clinical trial NCT00770328?

This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.

Where is trial NCT00770328 being conducted?

This trial has 1 study location across Tennessee. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.

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Data sourced from official public datasets. See our methodology for details. Retrieved and formatted by PlainTrial Editorial

Every figure on PlainTrial is rendered directly from the ClinicalTrials.gov registry, no number is typed in by an editor. This page mirrors this trial's own ClinicalTrials.gov registry record, live from the dataset. See our editorial standards & corrections policy, the methodology behind these numbers, or report a data error.