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NCT00769210 · ClinicalTrials.gov registry record · Early Phase 1
The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart Failure
A Early Phase 1 study, sponsored by University of Utah.
- Completed
- Registry status
- Early Phase 1
- Development phase
- 12
- Enrollment target
NCT00769210: Completed Early Phase 1 study, sponsored by University of Utah.
NCT00769210 is a Early Phase 1 study that has completed, run by University of Utah. The registered enrollment target is 12 participants, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (77% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00769210, a Early Phase 1 study, has completed, sponsored by University of Utah.
- COMPLETED
- Registry status
- Early Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
Our proposed research will examine whether treatment with simvastatin alters expression and activity of monocyte TF, whether polymorphisms in the TF gene alter the therapeutic effect and what effect treatment has on inflammatory markers in heart failure. The results of this study may assist in tailoring statin therapy to specific characteristics, such as inflammatory state, of heart failure patients. If treatment with simvastatin significantly lowers TF expression, this may reduce the risk of thromboembolic events in patients with heart failure, thus reducing mortality and morbidity. If the treatment effect varies based on the TF genotype, this may define an identifiable population in whom statin therapy may be more beneficial than the population as a whole.
Interventions
- DRUG Simvastatin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2005-05 |
| Est. Completion | 2008-07 |
| Phase | Early Phase 1 |
What the finished NCT00769210 record still lists
NCT00769210 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 53-participant average among 2,764 other Early Phase 1 trials with a reported enrollment target (77% lower).
The record links to 0 conditions, and to 1 intervention - of which Simvastatin is the first listed.
NCT00769210 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00769210 about?
NCT00769210 is a clinical study titled "The Effect of Simvastatin Therapy on the Expression of Procoagulant and Inflammatory Markers in Heart Failure". Our proposed research will examine whether treatment with simvastatin alters expression and activity of monocyte TF, whether polymorphisms in the TF gene alter the therapeutic effect and what effect treatment has on inflammatory markers in heart failure. The results of this study may assist in tailo...
What is the current status of trial NCT00769210?
This trial is currently completed. It is a Early Phase 1 study. The enrollment target is 12 participants. The study started on 2005-05. Estimated completion is 2008-07.
What interventions are being tested in trial NCT00769210?
The interventions under investigation include: Simvastatin (DRUG).
Who is sponsoring clinical trial NCT00769210?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00769210's enrollment target sits among peer trials
12 1530th of 2000 higher than 401 of 2,000 other Early Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Early Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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