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NCT00753142 · ClinicalTrials.gov registry record · NA
Mechanism Underlying Beta-cell Failure in Obese African Americans With History of Hyperglycemic Crises
A NA study, sponsored by Emory University.
- Completed
- Registry status
- NA
- Development phase
- 28
- Enrollment target
NCT00753142 is a NA study that has completed, run by Emory University. The registered enrollment target is 28 participants.
The verdict
NCT00753142, a NA study, has completed, sponsored by Emory University.
- COMPLETED
- Registry status
- NA
- Development phase
- 28 participants
- Enrollment target
Study Summary
Obesity is common in African American (AA) patients with newly diagnosed diabetes who present with diabetic ketoacidosis (DKA). Despite the presentation with severe symptoms of insulinopenia and ketoacidosis, clinical and immunogenetic observations indicate that most obese AA patients with DKA have type 2 diabetes. In such patients, previous studies reveal that: a) at presentation, obese AA patients with DKA have markedly decreased pancreatic insulin secretion, lower than in obese non-DKA patients admitted with comparable hyperglycemia, but significantly greater than in lean patients with DKA; b) aggressive diabetic management results in significant improvement in beta-cell function and insulin sensitivity sufficient to allow discontinuation of insulin therapy within 3 months of follow-up. Based on these observations the researchers conclude that similar to obese patients with hyperglycemia, most obese AA with DKA have type 2 diabetes, and that although defects in both insulin secretion and insulin action are present, transient b-cell failure is the primary defect in the development of ketoacidosis.
Interventions
- DRUG Intralipid 20%
- DRUG Glucose infusion
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 28 participants |
| Start Date | 2004-03 |
| Est. Completion | 2009-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00753142
The ClinicalTrials.gov registry entry for NCT00753142 describes a study currently listed as completed, categorized as NA. The registered enrollment target is 28 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is Emory University, which has 1,208 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Intralipid 20% is the first listed.
NCT00753142 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00753142 about?
NCT00753142 is a clinical study titled "Mechanism Underlying Beta-cell Failure in Obese African Americans With History of Hyperglycemic Crises". Obesity is common in African American (AA) patients with newly diagnosed diabetes who present with diabetic ketoacidosis (DKA). Despite the presentation with severe symptoms of insulinopenia and ketoacidosis, clinical and immunogenetic observations indicate that most obese AA patients with DKA have ...
What is the current status of trial NCT00753142?
This trial is currently completed. It is a NA study. The enrollment target is 28 participants. The study started on 2004-03. Estimated completion is 2009-12.
What interventions are being tested in trial NCT00753142?
The interventions under investigation include: Intralipid 20% (DRUG), Glucose infusion (DRUG).
Who is sponsoring clinical trial NCT00753142?
This trial is sponsored by Emory University, which has 1,208 total clinical trials registered on ClinicalTrials.gov.
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