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NCT00749515 · ClinicalTrials.gov registry record · Phase 4
Pilot Study for Patients With Poor Response to Deferasirox
A Phase 4 study, sponsored by Boston Children's Hospital.
- Completed
- Registry status
- Phase 4
- Development phase
- 15
- Enrollment target
NCT00749515: Completed Phase 4 study, sponsored by Boston Children's Hospital.
NCT00749515 is a Phase 4 study that has completed, run by Boston Children's Hospital. The registered enrollment target is 15 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00749515, a Phase 4 study, has completed, sponsored by Boston Children's Hospital.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 15 participants
- Enrollment target
Study Summary
This purpose of this study is to understand the differences between people who have a good response to deferasirox (exjade) compared to people who have a poor response to this medication when used for transfusion-dependent iron overload. The hypothesis is that patients with poor responses have physiologic barriers to deferasirox that may include absorption, pharmacokinetics of drug metabolism, hepatic clearance and/or genetic factors.
Primary Outcome
Area Under the Curve (AUC) 0 to 24 hours post dose
Interventions
- DRUG Deferoxamine
- DRUG Deferasirox
- RADIATION HIDA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 15 participants |
| Start Date | 2008-03 |
| Est. Completion | 2008-11 |
| Phase | Phase 4 |
What the finished NCT00749515 record still lists
NCT00749515 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 15 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (97% lower).
The record links to 0 conditions, and to 3 interventions - of which Deferoxamine is the first listed.
NCT00749515 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00749515 about?
NCT00749515 is a clinical study titled "Pilot Study for Patients With Poor Response to Deferasirox". This purpose of this study is to understand the differences between people who have a good response to deferasirox (exjade) compared to people who have a poor response to this medication when used for transfusion-dependent iron overload. The hypothesis is that patients with poor responses have phys...
What is the current status of trial NCT00749515?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 15 participants. The study started on 2008-03. Estimated completion is 2008-11.
What interventions are being tested in trial NCT00749515?
The interventions under investigation include: Deferoxamine (DRUG), Deferasirox (DRUG), HIDA (RADIATION).
Who is sponsoring clinical trial NCT00749515?
This trial is sponsored by Boston Children's Hospital, which has 462 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00749515's enrollment target sits among peer trials
15 1880th of 2000 higher than 100 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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