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NCT00747851 · ClinicalTrials.gov registry record
NETs: Protection or Harm in Neonatal Inflammation or Infection
A clinical trial of Necrotizing Enterocolitis (NEC), sponsored by University of Utah.
- Recruiting
- Registry status
- 388
- Enrollment target
- 1
- Study location
NCT00747851: Recruiting study of Necrotizing Enterocolitis (NEC), sponsored by University of Utah.
NCT00747851 is a study of Necrotizing Enterocolitis (NEC) that is actively recruiting participants, run by University of Utah. The registered enrollment target is 388 participants. The trial reports 1 study location across 1 state. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00747851, a study of Necrotizing Enterocolitis (NEC), is actively recruiting participants, sponsored by University of Utah.
- RECRUITING
- Registry status
- 388 participants
- Enrollment target
- 1
- Study location
Study Summary
This is a prospective in vitro cell biology study of polymorphonuclear leukocyte (PMN) protein synthesis in response to PAF. PMNs from cord blood of premature human infants at risk for NEC (birth weight between 501 - 1500 grams) and PMNs from cord blood of healthy term infants will be isolated and stimulated with PAF, a biologically active phospholipid implicated in the pathogenesis of NEC. NEC, a disease of prematurity with an incidence of 10.1% of infants born weighing between 501 - 1500 grams, is associated with significant morbidity and mortality. We will compare the protein synthesis of inflammatory modulators, including Interleukin 6 Receptor alpha (IL-6R alpha) and Retinoic Acid Receptor alpha (RAR alpha) proteins to protein synthesis responses already observed in PMNs isolated from healthy adults. Furthermore, we will characterize the expression and activity of the mammalian target of rapamycin (mTOR) translational protein synthesis control pathway in PMNs isolated from preterm and term infants and compare those results with previous observations in PMNs isolated from adults. This pathway is known to regulate IL-6R alpha and RAR alpha protein expression in PMNs isolated from adults. We will also follow those premature infants at risk for NEC clinically to determine which infants develop NEC and what risk factors may be associated with NEC in this population.
Conditions Studied
Study Locations (1)
Utah
- University of Utah - Salt Lake City
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 388 participants |
| Start Date | 2003-10 |
| Est. Completion | 2026-04-30 |
What NCT00747851 shows while recruiting
NCT00747851 is an observational study that tracks outcomes without assigning an intervention. The registered 388 participants enrollment target is mid-sized for trials with a published cap.
The record links to 1 condition, with Necrotizing Enterocolitis (NEC) appearing as the primary indexed condition, and to 0 interventions.
NCT00747851 reports a single indexed study location in Utah.
Frequently Asked Questions
What is clinical trial NCT00747851 about?
NCT00747851 is a clinical study titled "NETs: Protection or Harm in Neonatal Inflammation or Infection". This is a prospective in vitro cell biology study of polymorphonuclear leukocyte (PMN) protein synthesis in response to PAF. PMNs from cord blood of premature human infants at risk for NEC (birth weight between 501 - 1500 grams) and PMNs from cord blood of healthy term infants will be isolated and s...
What is the current status of trial NCT00747851?
This trial is currently recruiting. The enrollment target is 388 participants. The study started on 2003-10. Estimated completion is 2026-04-30.
What conditions does trial NCT00747851 study?
This clinical trial studies the following conditions: Necrotizing Enterocolitis (NEC).
Who is sponsoring clinical trial NCT00747851?
This trial is sponsored by University of Utah, which has 818 total clinical trials registered on ClinicalTrials.gov.
Where is trial NCT00747851 being conducted?
This trial has 1 study location across Utah. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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