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NCT00745732 · ClinicalTrials.gov registry record · Phase 1
Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)
A Phase 1 study, sponsored by M.D. Anderson Cancer Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 3
- Enrollment target
NCT00745732: Clinical Trial Phase 1 study, sponsored by M.D. Anderson Cancer Center.
NCT00745732 is a Phase 1 study that was terminated before completion, run by M.D. Anderson Cancer Center. The registered enrollment target is 3 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (95% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00745732, a Phase 1 study, was terminated before completion, sponsored by M.D. Anderson Cancer Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 3 participants
- Enrollment target
Study Summary
Primary Objectives: * To assess the safety of oral therapy with ZD6474 by evaluating the frequency, severity, and duration of treatment-emergent adverse events in patients with poor prognosis lung cancer. * To record the extent, frequency and duration of any tumor responses to this treatment regimen and assess whether ZD6474 augments the efficacy of radiation therapy in non-small cell lung cancer patients. * To determine the recommended phase II dose of ZD6474 for future clinical studies with radiation therapy. Secondary Objectives: * To determine the effects on metabolism and angiogenic factors by positron emission tomography (PET) scan/computed tomography (CT) scan , vascular endothelial growth factor (VEGF), and circulating endothelial cell levels in patients treated with ZD6474 and radiation therapy.
Interventions
- RADIATION Radiation Therapy
- DRUG ZD6474 (ZACTIMA)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2008-10-09 |
| Est. Completion | 2012-09 |
| Phase | Phase 1 |
Why NCT00745732 stopped before completion
NCT00745732 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 3 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (95% lower).
The record links to 0 conditions, and to 2 interventions - of which Radiation Therapy is the first listed.
NCT00745732 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00745732 about?
NCT00745732 is a clinical study titled "Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)". Primary Objectives: * To assess the safety of oral therapy with ZD6474 by evaluating the frequency, severity, and duration of treatment-emergent adverse events in patients with poor prognosis lung cancer. * To record the extent, frequency and duration of any tumor responses to this treatment regime...
What is the current status of trial NCT00745732?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 3 participants. The study started on 2008-10-09. Estimated completion is 2012-09.
What interventions are being tested in trial NCT00745732?
The interventions under investigation include: Radiation Therapy (RADIATION), ZD6474 (ZACTIMA) (DRUG).
Who is sponsoring clinical trial NCT00745732?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00745732's enrollment target sits among peer trials
3 1999th of 2000 higher than 1 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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