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NCT00745732 · ClinicalTrials.gov registry record · Phase 1
Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)
A Phase 1 study, sponsored by M.D. Anderson Cancer Center.
- Terminated
- Registry status
- Phase 1
- Development phase
- 3
- Enrollment target
NCT00745732: Clinical Trial Phase 1 study, sponsored by M.D. Anderson Cancer Center.
NCT00745732 is a Phase 1 study that was terminated before completion, run by M.D. Anderson Cancer Center. The registered enrollment target is 3 participants. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00745732, a Phase 1 study, was terminated before completion, sponsored by M.D. Anderson Cancer Center.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 3 participants
- Enrollment target
Study Summary
Primary Objectives: * To assess the safety of oral therapy with ZD6474 by evaluating the frequency, severity, and duration of treatment-emergent adverse events in patients with poor prognosis lung cancer. * To record the extent, frequency and duration of any tumor responses to this treatment regimen and assess whether ZD6474 augments the efficacy of radiation therapy in non-small cell lung cancer patients. * To determine the recommended phase II dose of ZD6474 for future clinical studies with radiation therapy. Secondary Objectives: * To determine the effects on metabolism and angiogenic factors by positron emission tomography (PET) scan/computed tomography (CT) scan , vascular endothelial growth factor (VEGF), and circulating endothelial cell levels in patients treated with ZD6474 and radiation therapy.
Interventions
- RADIATION Radiation Therapy
- DRUG ZD6474 (ZACTIMA)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 3 participants |
| Start Date | 2008-10-09 |
| Est. Completion | 2012-09 |
| Phase | Phase 1 |
Interested in This Trial?
Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00745732
The ClinicalTrials.gov registry entry for NCT00745732 describes a study currently listed as terminated, categorized as Phase 1. The registered enrollment target is 3 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is M.D. Anderson Cancer Center, which has 2,692 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 2 interventions - of which Radiation Therapy is the first listed.
NCT00745732 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00745732 about?
NCT00745732 is a clinical study titled "Radiation Therapy (XRT) and ZD6474 in Non-Small Cell Lung Cancer (NSCLC)". Primary Objectives: * To assess the safety of oral therapy with ZD6474 by evaluating the frequency, severity, and duration of treatment-emergent adverse events in patients with poor prognosis lung cancer. * To record the extent, frequency and duration of any tumor responses to this treatment regime...
What is the current status of trial NCT00745732?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 3 participants. The study started on 2008-10-09. Estimated completion is 2012-09.
What interventions are being tested in trial NCT00745732?
The interventions under investigation include: Radiation Therapy (RADIATION), ZD6474 (ZACTIMA) (DRUG).
Who is sponsoring clinical trial NCT00745732?
This trial is sponsored by M.D. Anderson Cancer Center, which has 2,692 total clinical trials registered on ClinicalTrials.gov.
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