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NCT00744328 · ClinicalTrials.gov registry record · Phase 4
Postpartum Depression: Transdermal Estradiol Versus Sertraline
A Phase 4 study, sponsored by Northwestern University.
- Terminated
- Registry status
- Phase 4
- Development phase
- 85
- Enrollment target
NCT00744328: Clinical Trial Phase 4 study, sponsored by Northwestern University.
NCT00744328 is a Phase 4 study that was terminated before completion, run by Northwestern University. The registered enrollment target is 85 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (84% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00744328, a Phase 4 study, was terminated before completion, sponsored by Northwestern University.
- TERMINATED
- Registry status
- Phase 4
- Development phase
- 85 participants
- Enrollment target
Study Summary
The purpose of this study is to determine whether estrogen patches are effective for the treatment of postpartum major depression, as compared to sertraline (Zoloft) and placebo.
Primary Outcome
Depression was assessed with the Structured Interview Guide for the Hamilton Depression Rating Scale - Atypical Depression Symptoms Version (SIGH-ADS29). The scale incorporates the 17 and 21-item Hamilton Rating Scales for Depression (HRSD) as well as 8 atypical symptoms of depression. Scores range from 0 to 90, where a higher score corresponds to a higher level of depressive symptomatology.
Interventions
- OTHER Placebo
- DRUG Sertraline
- DRUG Transdermal Estradiol
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 85 participants |
| Start Date | 2008-08 |
| Est. Completion | 2013-09 |
| Phase | Phase 4 |
Why NCT00744328 stopped before completion
NCT00744328 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 85 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (84% lower).
The record links to 0 conditions, and to 3 interventions - of which Placebo is the first listed.
NCT00744328 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00744328 about?
NCT00744328 is a clinical study titled "Postpartum Depression: Transdermal Estradiol Versus Sertraline". The purpose of this study is to determine whether estrogen patches are effective for the treatment of postpartum major depression, as compared to sertraline (Zoloft) and placebo.
What is the current status of trial NCT00744328?
This trial is currently terminated. It is a Phase 4 study. The enrollment target is 85 participants. The study started on 2008-08. Estimated completion is 2013-09.
What interventions are being tested in trial NCT00744328?
The interventions under investigation include: Placebo (OTHER), Sertraline (DRUG), Transdermal Estradiol (DRUG).
Who is sponsoring clinical trial NCT00744328?
This trial is sponsored by Northwestern University, which has 1,209 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00744328's enrollment target sits among peer trials
85 928th of 2000 higher than 1,072 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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