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D-dimer to Select Patients With First Unprovoked Venous Thromboembolism Who Can Have Anticoagulants Stopped at 3 Months
NCT00720915 · View on ClinicalTrials.gov ↗
Study Summary
The purpose of this study is to determine if the risk of recurrent venous thromboembolism (VTE) after stopping therapy is low and acceptable in patients with a first unprovoked proximal deep vein thrombosis (DVT) or pulmonary embolism (PE) who have completed 3 months of therapy and who have a negative D-dimer test on therapy and 1 month after stopping therapy.
Conditions Studied
Interventions
- OTHER Discontinue anticoagulant therapy (Negative d-dimer)
- OTHER Continue on anticoagulant therapy (positive d-dimer)
Study Locations (13)
Ontario
- Hamilton General Hospital — Hamilton
- McMaster University — Hamilton
- St. Joseph's Health Care Centre — Hamilton
- Henderson Hospital — Hamilton
Massachusetts
- Brigham and Women's Hospital — Boston
- Beth Israel Deaconess Medical Centre — Boston
Other
- Limerick, Mid Western Regional Hospital — Limerick
- Addenbrooke's Hospital — Cambridge
District of Columbia
- Lombardi Cancer Center — Washington D.C.
Iowa
- University of Iowa Hospitals and Clinics — Iowa City
Michigan
- Henry Ford Hospital — Detroit
North Carolina
- UNC Thrombophilia Program — Chapel Hill
Utah
- Intermountain Medical Centre — Murray
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 410 participants |
| Start Date | 2008-09 |
| Est. Completion | 2016-12 |
| Phase | NA |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00720915
The ClinicalTrials.gov registry entry for NCT00720915 describes a study currently listed as completed. It is categorized as NA, which is the standard way researchers label where a study sits along the investigational pathway from early safety work through later efficacy and post-marketing evaluation. The registered enrollment target is 410 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is McMaster University, which has 13 total studies on file at ClinicalTrials.gov, and sponsors are the parties responsible for study design, oversight, and regulatory filings.
The record links to 2 conditions, with Pulmonary Embolism appearing as the primary indexed condition, and to 2 interventions — of which Discontinue anticoagulant therapy (Negative d-dimer) is the first listed. Interventions can include drugs, devices, procedures, behavioral programs, or observational arms, and each is tracked as a separate registry field so that downstream queries can filter accurately. When a trial lists multiple interventions, it usually reflects a multi-arm design or a comparison protocol rather than a single treatment being tested in isolation. The brief summary published in the registry is the clearest source of protocol intent and should be read before drawing conclusions from any sidebar tags.
Geographic footprint matters for practical reasons: NCT00720915 reports 13 study locations spanning 8 distinct geographic areas — top geographies include Ontario, Massachusetts, Other. A larger site network tends to correlate with broader recruitment capacity, but it does not imply anything about study quality, and site-level enrollment status can diverge from the overall registry status shown above. Every data point on this page comes from the public ClinicalTrials.gov dataset and is reproduced here for reference only; it is not a medical recommendation, an endorsement of the sponsor, or an invitation to enroll. Verify current status, eligibility criteria, and contact details directly at ClinicalTrials.gov, and discuss any participation decision with your own healthcare provider.
Frequently Asked Questions
What is clinical trial NCT00720915 about?
NCT00720915 is a clinical study titled "D-dimer to Select Patients With First Unprovoked Venous Thromboembolism Who Can Have Anticoagulants Stopped at 3 Months". The purpose of this study is to determine if the risk of recurrent venous thromboembolism (VTE) after stopping therapy is low and acceptable in patients with a first unprovoked proximal deep vein thrombosis (DVT) or pulmonary embolism (PE) who have completed 3 months of therapy and who have a negati...
What is the current status of trial NCT00720915?
This trial is currently completed. It is a NA study. The enrollment target is 410 participants. The study started on 2008-09. Estimated completion is 2016-12.
What conditions does trial NCT00720915 study?
This clinical trial studies the following conditions: Pulmonary Embolism, Deep Vein Thrombosis. These conditions were identified from the trial registry and reflect the primary focus areas of the research.
What interventions are being tested in trial NCT00720915?
The interventions under investigation include: Discontinue anticoagulant therapy (Negative d-dimer) (OTHER), Continue on anticoagulant therapy (positive d-dimer) (OTHER). Each intervention is being evaluated for safety and efficacy as part of this clinical study.
Who is sponsoring clinical trial NCT00720915?
This trial is sponsored by McMaster University, which has 13 total clinical trials registered on ClinicalTrials.gov. The sponsor is responsible for the study's design, funding, and regulatory compliance.
Where is trial NCT00720915 being conducted?
This trial has 13 study locations across District of Columbia, Iowa, Massachusetts, Michigan, North Carolina. Contact the study sites directly through ClinicalTrials.gov for enrollment availability.
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