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NCT00706459 · ClinicalTrials.gov registry record
Advanced MR Imaging in Patients With Painful, Degenerative Disc Disease: A Pilot Study
A clinical trial, sponsored by University of California, San Francisco.
- Terminated
- Registry status
- 53
- Enrollment target
NCT00706459 is a clinical trial that was terminated before completion, run by University of California, San Francisco. The registered enrollment target is 53 participants.
The verdict
NCT00706459 was terminated before completion, sponsored by University of California, San Francisco.
- TERMINATED
- Registry status
- 53 participants
- Enrollment target
Study Summary
In this study, we will use advanced and newly available MR imaging techniques at 3 Tesla (including in situ axial loading and quantitative T1rho, T2, and diffusion measurements) to assess the intervertebral discs and adjacent vertebrae in patients with lumbar back pain scheduled for back surgery (n=20), patients with degenerative disease without classic discogenic back pain (n=10), patients who had discectomies for herniated discs (n=5), and age-matched volunteers without back pain (n=10). In all patients standard imaging procedures will also be performed, including radiographs, standard MRI at 1.5 Tesla and discography. All patients will have specimen of the intervertebral disc harvested at surgery and pathologic analysis and spectroscopy of these specimen will be performed. Post-surgical findings/outcome combined with discography will serve as a standard of reference for the identification of the painful disc(s). The diagnostic performance of the new techniques in assessing the painful disc will be evaluated. We will collect disc specimens from 50 patients undergoing back surgery but did not have pre-surgical MR imaging. These disc specimens will be analyzed in the same manner as the specimens collected from surgical patients who had pre-surgical MRI. This study will serve as a pilot study for a larger project focusing on advanced imaging of the painful intervertebral disc. We hypothesis that advanced, dedicated MR examinations at 3T can identify painful degenerated discs in patients with chronic lumbar back pain.
Interventions
- DEVICE Magnetic Resonance Imaging
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 53 participants |
| Start Date | 2005-03 |
| Est. Completion | 2009-12 |
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Full Details on ClinicalTrials.gov ↗What the Registry Record Tells You About NCT00706459
The ClinicalTrials.gov registry entry for NCT00706459 describes a study currently listed as terminated, categorized as an unspecified phase. The registered enrollment target is 53 participants, a figure that helps gauge the scale of data the investigators plan to collect. The listed sponsor is University of California, San Francisco, which has 1,713 total studies on file at ClinicalTrials.gov.
The record links to 0 conditions, and to 1 intervention - of which Magnetic Resonance Imaging is the first listed.
NCT00706459 reports 0 study locations.
Frequently Asked Questions
What is clinical trial NCT00706459 about?
NCT00706459 is a clinical study titled "Advanced MR Imaging in Patients With Painful, Degenerative Disc Disease: A Pilot Study". In this study, we will use advanced and newly available MR imaging techniques at 3 Tesla (including in situ axial loading and quantitative T1rho, T2, and diffusion measurements) to assess the intervertebral discs and adjacent vertebrae in patients with lumbar back pain scheduled for back surgery (n=...
What is the current status of trial NCT00706459?
This trial is currently terminated. The enrollment target is 53 participants. The study started on 2005-03. Estimated completion is 2009-12.
What interventions are being tested in trial NCT00706459?
The interventions under investigation include: Magnetic Resonance Imaging (DEVICE).
Who is sponsoring clinical trial NCT00706459?
This trial is sponsored by University of California, San Francisco, which has 1,713 total clinical trials registered on ClinicalTrials.gov.
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