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NCT00706446 · ClinicalTrials.gov registry record · NA
The Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic Variations
A NA study, sponsored by Brigham and Women's Hospital.
- Terminated
- Registry status
- NA
- Development phase
- 255
- Enrollment target
NCT00706446: Clinical Trial NA study, sponsored by Brigham and Women's Hospital.
NCT00706446 is a NA study that was terminated before completion, run by Brigham and Women's Hospital. The registered enrollment target is 255 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (82% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00706446, a NA study, was terminated before completion, sponsored by Brigham and Women's Hospital.
- TERMINATED
- Registry status
- NA
- Development phase
- 255 participants
- Enrollment target
Study Summary
This study is looking at the effects of certain long-acting bronchodilators on patients with asthma who have specific genetic variations. The investigators are interested in a certain common genetic variation in the receptor for beta-agonists, which is found in as many of one-sixth of the population. There is evidence that patients with asthma who have this variation may not do as well when treated with albuterol on a regular basis. The investigators will be looking at whether patients with this variation have more asthma exacerbations over the course of a year when treated with salmeterol or formoterol, which are long-acting forms of albuterol; and whether these patients have fewer exacerbations when treated with tiotropium, which is a different long-acting bronchodilator that does not act at this receptor. In both groups patients will also be receiving inhaled steroids.
Interventions
- DRUG Salmeterol
- DRUG Formoterol
- DRUG Fluticasone propionate
- DRUG tiotropium bromide
- DRUG budesonide
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 255 participants |
| Start Date | 2008-06 |
| Est. Completion | 2011-09 |
| Phase | NA |
Why NCT00706446 stopped before completion
NCT00706446 is an interventional study that assigns participants to a tested intervention. The registered 255 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (82% lower).
The record links to 0 conditions, and to 5 interventions - of which Salmeterol is the first listed.
NCT00706446 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00706446 about?
NCT00706446 is a clinical study titled "The Effects of Different Long-acting Bronchodilator Medications on Asthma Patients With Different Genetic Variations". This study is looking at the effects of certain long-acting bronchodilators on patients with asthma who have specific genetic variations. The investigators are interested in a certain common genetic variation in the receptor for beta-agonists, which is found in as many of one-sixth of the population...
What is the current status of trial NCT00706446?
This trial is currently terminated. It is a NA study. The enrollment target is 255 participants. The study started on 2008-06. Estimated completion is 2011-09.
What interventions are being tested in trial NCT00706446?
The interventions under investigation include: Salmeterol (DRUG), Formoterol (DRUG), Fluticasone propionate (DRUG), tiotropium bromide (DRUG), budesonide (DRUG).
Who is sponsoring clinical trial NCT00706446?
This trial is sponsored by Brigham and Women's Hospital, which has 937 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00706446's enrollment target sits among peer trials
255 407th of 2000 higher than 1,594 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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