Medical Information Only. Always consult your healthcare provider before enrolling in any clinical trial.
NCT00705120 · ClinicalTrials.gov registry record · Phase 1
Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantation
A Phase 1 study, sponsored by St. Jude Children's Research Hospital.
- Completed
- Registry status
- Phase 1
- Development phase
- 9
- Enrollment target
NCT00705120: Completed Phase 1 study, sponsored by St. Jude Children's Research Hospital.
NCT00705120 is a Phase 1 study that has completed, run by St. Jude Children's Research Hospital. The registered enrollment target is 9 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00705120, a Phase 1 study, has completed, sponsored by St. Jude Children's Research Hospital.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 9 participants
- Enrollment target
Study Summary
This protocol was a prospective, Phase I study of allogeneic bone marrow transplantation (BMT) as the primary therapy for Osteogenesis Imperfecta Types II and III. Compatible sibling donors and unrelated donors were stratified and analyzed according to the type of donor. All patients with a sibling donor will received a chemotherapy conditioning regimen; a non-T cell depleted allogeneic marrow, and GVHD prophylaxis. All patients with an unrelated donor will receive a chemoradiotherapy conditioning regimen, a T-cell depleted allogeneic marrow, and GVHD prophylaxis. The primary objective of this study was to investigate the safety and toxicity of these BMT procedures in this particular population.
Interventions
- DRUG Cyclophosphamide
- PROCEDURE Mesenchymal Stem Cell Transplantation
- DRUG Cyclosporin
- OTHER Bone Marrow Cell Transplantation
- RADIATION Irradiation, Total Body
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 9 participants |
| Start Date | 1995-11 |
| Est. Completion | 2007-10 |
| Phase | Phase 1 |
What the finished NCT00705120 record still lists
NCT00705120 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 9 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (85% lower).
The record links to 0 conditions, and to 5 interventions - of which Cyclophosphamide is the first listed.
NCT00705120 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00705120 about?
NCT00705120 is a clinical study titled "Treatment of Severe Osteogenesis Imperfecta by Allogeneic Bone Marrow Transplantation". This protocol was a prospective, Phase I study of allogeneic bone marrow transplantation (BMT) as the primary therapy for Osteogenesis Imperfecta Types II and III. Compatible sibling donors and unrelated donors were stratified and analyzed according to the type of donor. All patients with a sibling ...
What is the current status of trial NCT00705120?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 9 participants. The study started on 1995-11. Estimated completion is 2007-10.
What interventions are being tested in trial NCT00705120?
The interventions under investigation include: Cyclophosphamide (DRUG), Mesenchymal Stem Cell Transplantation (PROCEDURE), Cyclosporin (DRUG), Bone Marrow Cell Transplantation (OTHER), Irradiation, Total Body (RADIATION).
Who is sponsoring clinical trial NCT00705120?
This trial is sponsored by St. Jude Children's Research Hospital, which has 410 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00705120's enrollment target sits among peer trials
9 1955th of 2000 higher than 42 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
Nationwide trials with similar profiles
Cross-condition peers matched on enrollment target and registry start date, not the same-condition list above.
Similar registry start date
- NCT05988463 · started 2027-01-01 · Phase 1
Dose-Escalation Study of Artesunate Patients With IPF
- NCT07219706 · started 2026-12-10 · NA
Dietary Fiber and Time Restricted Eating
- NCT02831335 · started 2026-12-01
Technical Development of Multi-Parametric Renocerebral MRI
- NCT05962346 · started 2026-12 · NA
Fetal Endoscopic Tracheal Occlusion for Congenital Diaphragmatic Hernia