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NCT00700999 · ClinicalTrials.gov registry record · Phase 4
Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)
A Phase 4 study, sponsored by US Department of Veterans Affairs.
- Completed
- Registry status
- Phase 4
- Development phase
- 65
- Enrollment target
NCT00700999: Completed Phase 4 study, sponsored by US Department of Veterans Affairs.
NCT00700999 is a Phase 4 study that has completed, run by US Department of Veterans Affairs. The registered enrollment target is 65 participants, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (87% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00700999, a Phase 4 study, has completed, sponsored by US Department of Veterans Affairs.
- COMPLETED
- Registry status
- Phase 4
- Development phase
- 65 participants
- Enrollment target
Study Summary
The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can predict who will get better with treatment.
Primary Outcome
Mean percent change in brain response in the prefrontal cortex during an emotion reappraisal task in the treatment (paroxetine) group and in the Combat Exposed Control group. Target areas are analyzed from fMRI scans which were completed before participants receive treatment and again after participants received 12 weeks of treatment with paroxetine (20-40mg QD). Combat Exposed Control participants received an fMRI scan after signing initial consent and again 12 weeks later.
Interventions
- DRUG Paroxetine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 65 participants |
| Start Date | 2008-10 |
| Est. Completion | 2012-03 |
| Phase | Phase 4 |
What the finished NCT00700999 record still lists
NCT00700999 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 65 participants, a relatively small participant target, below the 518-participant average among 9,235 other Phase 4 trials with a reported enrollment target (87% lower).
The record links to 0 conditions, and to 1 intervention - of which Paroxetine is the first listed.
NCT00700999 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00700999 about?
NCT00700999 is a clinical study titled "Brain Markers of Treatment Response in Post-Traumatic Stress Disorder (PTSD)". The purpose of this study is to examine if treatment of post-traumatic stress disorder in combat veterans with paroxetine changes brain responses as measured by functional magnetic resonance imaging and if brain responses can predict who will get better with treatment.
What is the current status of trial NCT00700999?
This trial is currently completed. It is a Phase 4 study. The enrollment target is 65 participants. The study started on 2008-10. Estimated completion is 2012-03.
What interventions are being tested in trial NCT00700999?
The interventions under investigation include: Paroxetine (DRUG).
Who is sponsoring clinical trial NCT00700999?
This trial is sponsored by US Department of Veterans Affairs, which has 632 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00700999's enrollment target sits among peer trials
65 1091st of 2000 higher than 903 of 2,000 other Phase 4 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 4 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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