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NCT00682786 · ClinicalTrials.gov registry record · Phase 2
Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma
A Phase 2 study, sponsored by Washington University School of Medicine.
- Completed
- Registry status
- Phase 2
- Development phase
- 135
- Enrollment target
NCT00682786: Completed Phase 2 study, sponsored by Washington University School of Medicine.
NCT00682786 is a Phase 2 study that has completed, run by Washington University School of Medicine. The registered enrollment target is 135 participants, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target. According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00682786, a Phase 2 study, has completed, sponsored by Washington University School of Medicine.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 135 participants
- Enrollment target
Study Summary
Determine if genotype-directed neoadjuvant chemoradiation, using information from the thymidylate synthase promoter polymorphism, result in a greater degree of tumor downstaging in high risk patients compared to historical controls.
Primary Outcome
Tumor downstaging (DS) is defined as a decrease in the T stage of the primary tumor by at least 1. Historical studies demonstrate a DS rate of 45%.
Interventions
- DRUG Irinotecan
- RADIATION Radiation
- DRUG 5FU
- PROCEDURE Surgery of resectable lesions
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 135 participants |
| Start Date | 2002-10 |
| Est. Completion | 2010-08 |
| Phase | Phase 2 |
What the finished NCT00682786 record still lists
NCT00682786 is an interventional study that assigns participants to a tested intervention. The registered 135 participants enrollment target is mid-sized for trials with a published cap, roughly in line with the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target.
The record links to 0 conditions, and to 4 interventions - of which Irinotecan is the first listed.
NCT00682786 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00682786 about?
NCT00682786 is a clinical study titled "Genotype-directed Neoadjuvant Chemoradiation for Rectal Carcinoma". Determine if genotype-directed neoadjuvant chemoradiation, using information from the thymidylate synthase promoter polymorphism, result in a greater degree of tumor downstaging in high risk patients compared to historical controls.
What is the current status of trial NCT00682786?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 135 participants. The study started on 2002-10. Estimated completion is 2010-08.
What interventions are being tested in trial NCT00682786?
The interventions under investigation include: Irinotecan (DRUG), Radiation (RADIATION), 5FU (DRUG), Surgery of resectable lesions (PROCEDURE).
Who is sponsoring clinical trial NCT00682786?
This trial is sponsored by Washington University School of Medicine, which has 1,502 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00682786's enrollment target sits among peer trials
135 532nd of 2000 higher than 1,464 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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