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NCT00680589 · ClinicalTrials.gov registry record · Phase 1
Patients With Mouse Tyrp2 DNA: A Phase I Trial to Assess Safety and Immune Response
A Phase 1 study, sponsored by Memorial Sloan Kettering Cancer Center.
- Completed
- Registry status
- Phase 1
- Development phase
- 12
- Enrollment target
NCT00680589: Completed Phase 1 study, sponsored by Memorial Sloan Kettering Cancer Center.
NCT00680589 is a Phase 1 study that has completed, run by Memorial Sloan Kettering Cancer Center. The registered enrollment target is 12 participants, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00680589, a Phase 1 study, has completed, sponsored by Memorial Sloan Kettering Cancer Center.
- COMPLETED
- Registry status
- Phase 1
- Development phase
- 12 participants
- Enrollment target
Study Summary
The goal of this study is to find out about the safety of injecting the gene (DNA) for mouse TYRP2 in patients with melanoma. DNA is a material that contains the information needed to produce many substances in the body. TYRP2 is a substance found in melanoma cells that helps to produce their black color. The DNA used in this study is the gene for mouse TYRP2. The gene is introduced into bacteria, which are grown in large quantities. The DNA vaccine is then made from bacteria that is inactive. We would like to see if we can immunize patients against TYRP2 by injecting mouse TYRP2 DNA. We will also follow the patients closely to see if there are any side effects. Mouse TYRP2 DNA is very similar to human TYRP2 DNA. We believe, based on lab experiments, that injection of mouse TYRP2 DNA could result in the production of immune substances (antibodies and T cells) that recognize melanoma cells. Antibodies are substances produced by your immune system to defend your body against bacteria and viruses. T cells are a type of white blood cell that can also fight infections. The small differences between mouse and human TYRP2 may allow your immune system to make the antibodies and T cells against melanoma. There is no evidence yet that injection of TYRP2 DNA results in any clinical benefit in patients.
Interventions
- BIOLOGICAL injection of mouse TYRP2 DNA
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 12 participants |
| Start Date | 2006-07 |
| Est. Completion | 2011-03 |
| Phase | Phase 1 |
What the finished NCT00680589 record still lists
NCT00680589 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 12 participants, a relatively small participant target, below the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (80% lower).
The record links to 0 conditions, and to 1 intervention - of which injection of mouse TYRP2 DNA is the first listed.
NCT00680589 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00680589 about?
NCT00680589 is a clinical study titled "Patients With Mouse Tyrp2 DNA: A Phase I Trial to Assess Safety and Immune Response". The goal of this study is to find out about the safety of injecting the gene (DNA) for mouse TYRP2 in patients with melanoma. DNA is a material that contains the information needed to produce many substances in the body. TYRP2 is a substance found in melanoma cells that helps to produce their black ...
What is the current status of trial NCT00680589?
This trial is currently completed. It is a Phase 1 study. The enrollment target is 12 participants. The study started on 2006-07. Estimated completion is 2011-03.
What interventions are being tested in trial NCT00680589?
The interventions under investigation include: injection of mouse TYRP2 DNA (BIOLOGICAL).
Who is sponsoring clinical trial NCT00680589?
This trial is sponsored by Memorial Sloan Kettering Cancer Center, which has 1,884 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00680589's enrollment target sits among peer trials
12 1852nd of 2000 higher than 90 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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