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NCT00672256 · ClinicalTrials.gov registry record · NA
Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence
A NA study, sponsored by Duke University.
- Completed
- Registry status
- NA
- Development phase
- 62
- Enrollment target
NCT00672256: Completed NA study, sponsored by Duke University.
NCT00672256 is a NA study that has completed, run by Duke University. The registered enrollment target is 62 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00672256, a NA study, has completed, sponsored by Duke University.
- COMPLETED
- Registry status
- NA
- Development phase
- 62 participants
- Enrollment target
Study Summary
The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in response inhibition during smoking abstinence. We will measure changes in performance and regional blood oxygenation levels using functional magnetic resonance imaging (fMRI)while smokers complete tasks designed to assess decision making and response inhibition. Our primary hypothesis is that smoking abstinence will result in impaired response inhibition accompanied by decreases in blood-oxygenation-level-dependent (BOLD) fMRI signal in brain regions associated with these cognitive processes including frontal cortex and the ventral striatum. Abstinence may also result in performance-related increases in activation in brain regions associated with effortful processing including the anterior cingulate cortex in effort to compensate for deficits in other regions.
Primary Outcome
Percent signal change in fMRI BOLD response in rIFC to correctly inhibited targets (as compared to control trials) during a response inhibition task following smoking as usual. Response inhibition trials are trials in the task in which the participant must inhibit a response (not press the button)when presented with a No-Go trial. Control trials are trials in the task in which the participant must press the button when presented with a Go trial.
Interventions
- BEHAVIORAL Smoking Abstinence
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 62 participants |
| Start Date | 2007-01 |
| Est. Completion | 2009-03 |
| Phase | NA |
What the finished NCT00672256 record still lists
NCT00672256 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 62 participants, a relatively small participant target, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (96% lower).
The record links to 0 conditions, and to 1 intervention - of which Smoking Abstinence is the first listed.
NCT00672256 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00672256 about?
NCT00672256 is a clinical study titled "Neuroimaging Decision Making and Response Inhibition During Smoking Abstinence". The broad objective of this proposal is to identify functional neuroanatomical correlates of impairments in response inhibition during smoking abstinence. We will measure changes in performance and regional blood oxygenation levels using functional magnetic resonance imaging (fMRI)while smokers comp...
What is the current status of trial NCT00672256?
This trial is currently completed. It is a NA study. The enrollment target is 62 participants. The study started on 2007-01. Estimated completion is 2009-03.
What interventions are being tested in trial NCT00672256?
The interventions under investigation include: Smoking Abstinence (BEHAVIORAL).
Who is sponsoring clinical trial NCT00672256?
This trial is sponsored by Duke University, which has 1,725 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00672256's enrollment target sits among peer trials
62 1157th of 2000 higher than 837 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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