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NCT00665925 · ClinicalTrials.gov registry record · Phase 2
Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis
A Phase 2 study, sponsored by Rigel Pharmaceuticals.
- Completed
- Registry status
- Phase 2
- Development phase
- 457
- Enrollment target
NCT00665925: Completed Phase 2 study, sponsored by Rigel Pharmaceuticals.
NCT00665925 is a Phase 2 study that has completed, run by Rigel Pharmaceuticals. The registered enrollment target is 457 participants, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (244% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00665925, a Phase 2 study, has completed, sponsored by Rigel Pharmaceuticals.
- COMPLETED
- Registry status
- Phase 2
- Development phase
- 457 participants
- Enrollment target
Study Summary
The purpose of this study is to determine whether the Spleen Tyrosine Kinase (Syk) inhibitor, R935788 (R788), at a dose of 100 mg, orally, twice-a-day, and/or a dose of of 150 mg, orally, once-a-day is effective in the treatment of Rheumatoid Arthrits in patients who have had an inadequate clinical response to methotrexate.
Primary Outcome
The number of participants with greater than or equal to 20% improvement in tender and swollen joint counts, AND in any 3 of the following: physician's assessment of disease activity, patient's assessment of disease activity, patient's assessment of pain, HAQ-DI; and C-Reactive Protein (CRP) or erythrocyte sedimentation rate (ESR), after 6 months
Interventions
- DRUG Placebo
- DRUG Fostamatinib disodium (R935788)
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 457 participants |
| Start Date | 2008-05 |
| Est. Completion | 2009-06 |
| Phase | Phase 2 |
What the finished NCT00665925 record still lists
NCT00665925 is an interventional study that assigns participants to a tested intervention. The registered 457 participants enrollment target is mid-sized for trials with a published cap, above the 133-participant average among 30,622 other Phase 2 trials with a reported enrollment target (244% higher).
The record links to 0 conditions, and to 2 interventions - of which Placebo is the first listed.
NCT00665925 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00665925 about?
NCT00665925 is a clinical study titled "Efficacy and Safety Study of R935788 Tablets to Treat Rheumatoid Arthritis". The purpose of this study is to determine whether the Spleen Tyrosine Kinase (Syk) inhibitor, R935788 (R788), at a dose of 100 mg, orally, twice-a-day, and/or a dose of of 150 mg, orally, once-a-day is effective in the treatment of Rheumatoid Arthrits in patients who have had an inadequate clinical ...
What is the current status of trial NCT00665925?
This trial is currently completed. It is a Phase 2 study. The enrollment target is 457 participants. The study started on 2008-05. Estimated completion is 2009-06.
What interventions are being tested in trial NCT00665925?
The interventions under investigation include: Placebo (DRUG), Fostamatinib disodium (R935788) (DRUG).
Who is sponsoring clinical trial NCT00665925?
This trial is sponsored by Rigel Pharmaceuticals, which has 22 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00665925's enrollment target sits among peer trials
457 84th of 2000 higher than 1,917 of 2,000 other Phase 2 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 2 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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