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NCT00655642 · ClinicalTrials.gov registry record · NA
Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED
A NA study, sponsored by Vanderbilt University.
- Terminated
- Registry status
- NA
- Development phase
- 171
- Enrollment target
NCT00655642: Clinical Trial NA study, sponsored by Vanderbilt University.
NCT00655642 is a NA study that was terminated before completion, run by Vanderbilt University. The registered enrollment target is 171 participants, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (88% lower). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00655642, a NA study, was terminated before completion, sponsored by Vanderbilt University.
- TERMINATED
- Registry status
- NA
- Development phase
- 171 participants
- Enrollment target
Study Summary
The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population. We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dose of metoclopramide, promethazine or normal saline placebo in undifferentiated adult emergency department patients.
Primary Outcome
Participants independently rated their nausea severity on separate scales at the baseline and 30-minute evaluations to prevent the baseline VAS score from influencing the 30-minute mark. The VAS had the words "Least Severe" on the left and "Most Severe" on the right. The possible values range from 0 to 100mm with 0 at the "Least Severe" extreme and 100 at the "Most Severe" extreme. Investigators instructed the participant to draw a single vertical line through the point on the 100mm scale that c
Interventions
- DRUG Ondansetron
- DRUG Normal Saline
- DRUG Metoclopramide
- DRUG Promethazine
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 171 participants |
| Start Date | 2007-03 |
| Est. Completion | 2008-10 |
| Phase | NA |
Why NCT00655642 stopped before completion
NCT00655642 is an interventional study that assigns participants to a tested intervention. The registered 171 participants enrollment target is mid-sized for trials with a published cap, below the 1,404-participant average among 58,714 other NA trials with a reported enrollment target (88% lower).
The record links to 0 conditions, and to 4 interventions - of which Ondansetron is the first listed.
NCT00655642 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00655642 about?
NCT00655642 is a clinical study titled "Comparison of Ondansetron, Metoclopramide and Promethazine for the Treatment of Nausea and Vomiting in the Adult ED". The purpose of this study is to compare the effectiveness of ondansetron, metoclopramide, and promethazine for the treatment of nausea in the adult emergency department population. We hypothesize that a single intravenous dose of ondansetron is more effective in reducing nausea than a single IV dos...
What is the current status of trial NCT00655642?
This trial is currently terminated. It is a NA study. The enrollment target is 171 participants. The study started on 2007-03. Estimated completion is 2008-10.
What interventions are being tested in trial NCT00655642?
The interventions under investigation include: Ondansetron (DRUG), Normal Saline (DRUG), Metoclopramide (DRUG), Promethazine (DRUG).
Who is sponsoring clinical trial NCT00655642?
This trial is sponsored by Vanderbilt University, which has 430 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00655642's enrollment target sits among peer trials
171 612th of 2000 higher than 1,387 of 2,000 other NA trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other NA trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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