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NCT00643058 · ClinicalTrials.gov registry record · Phase 1
Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II
A Phase 1 study, sponsored by John Sundy.
- Terminated
- Registry status
- Phase 1
- Development phase
- 70
- Enrollment target
NCT00643058: Clinical Trial Phase 1 study, sponsored by John Sundy.
NCT00643058 is a Phase 1 study that was terminated before completion, run by John Sundy. The registered enrollment target is 70 participants, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% higher). According to ClinicalTrials.gov, the official US trial registry.
The verdict
NCT00643058, a Phase 1 study, was terminated before completion, sponsored by John Sundy.
- TERMINATED
- Registry status
- Phase 1
- Development phase
- 70 participants
- Enrollment target
Study Summary
The purpose of the study is to determine the role of nitric oxide (NO) in asthma and to characterize the symptoms associated with inhaled endotoxin (lipopolysaccharide \[LPS\]) in normal subjects. In this study, we will determine the effect of inhaled endotoxin on exhaled NO in healthy African Americans, with and without NOS2 promoter polymorphisms. The protocol described in this submission will involve the use of NIH Clinical Center Reference Endotoxin which has been approved by the FDA under IND BB-IND-10035.
Interventions
- BIOLOGICAL LPS endotoxin
Trial Details
| Field | Value |
|---|---|
| Enrollment Target | 70 participants |
| Start Date | 2003-04 |
| Est. Completion | 2009-12 |
| Phase | Phase 1 |
Why NCT00643058 stopped before completion
NCT00643058 is an interventional study that assigns participants to a tested intervention. The registry caps enrollment at 70 participants, a relatively small participant target, above the 60-participant average among 29,502 other Phase 1 trials with a reported enrollment target (17% higher).
The record links to 0 conditions, and to 1 intervention - of which LPS endotoxin is the first listed.
NCT00643058 does not publish any study locations in the registry export this page uses.
Frequently Asked Questions
What is clinical trial NCT00643058 about?
NCT00643058 is a clinical study titled "Nitric Oxide, LPS and the Pathogenesis of Asthma Phase II". The purpose of the study is to determine the role of nitric oxide (NO) in asthma and to characterize the symptoms associated with inhaled endotoxin (lipopolysaccharide \[LPS\]) in normal subjects. In this study, we will determine the effect of inhaled endotoxin on exhaled NO in healthy African Ameri...
What is the current status of trial NCT00643058?
This trial is currently terminated. It is a Phase 1 study. The enrollment target is 70 participants. The study started on 2003-04. Estimated completion is 2009-12.
What interventions are being tested in trial NCT00643058?
The interventions under investigation include: LPS endotoxin (BIOLOGICAL).
Who is sponsoring clinical trial NCT00643058?
This trial is sponsored by John Sundy, which has 6 total clinical trials registered on ClinicalTrials.gov.
Learn More About Clinical Trials
How this trial's enrollment target compares
Where NCT00643058's enrollment target sits among peer trials
70 749th of 2000 higher than 1,227 of 2,000 other Phase 1 trials
participants (enrollment target), bucketed by value
Each bar is a band; taller bars hold more other Phase 1 trials. The dashed line + filled bar mark this entry. Hover or tap any bar for its full count and share, and where it sits relative to this entry.
Source ClinicalTrials.gov registry export · 2026-08-08
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